Cytochrome P450-mediated drug interactions

D. A. Flockhart, J. R. Oesterheld

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data.

Original languageEnglish
Pages (from-to)43-76
Number of pages34
JournalChild and Adolescent Psychiatric Clinics of North America
Volume9
Issue number1
StatePublished - 2000

Fingerprint

Drug Interactions
Cytochrome P-450 Enzyme System
Psychiatry
Formularies
PubMed
Pharmaceutical Preparations
Internet

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pediatrics, Perinatology, and Child Health

Cite this

Cytochrome P450-mediated drug interactions. / Flockhart, D. A.; Oesterheld, J. R.

In: Child and Adolescent Psychiatric Clinics of North America, Vol. 9, No. 1, 2000, p. 43-76.

Research output: Contribution to journalArticle

Flockhart, DA & Oesterheld, JR 2000, 'Cytochrome P450-mediated drug interactions', Child and Adolescent Psychiatric Clinics of North America, vol. 9, no. 1, pp. 43-76.
Flockhart, D. A. ; Oesterheld, J. R. / Cytochrome P450-mediated drug interactions. In: Child and Adolescent Psychiatric Clinics of North America. 2000 ; Vol. 9, No. 1. pp. 43-76.
@article{5d8810d3aaf64d7598bbc72c6bbcc659,
title = "Cytochrome P450-mediated drug interactions",
abstract = "In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data.",
author = "Flockhart, {D. A.} and Oesterheld, {J. R.}",
year = "2000",
language = "English",
volume = "9",
pages = "43--76",
journal = "Child and Adolescent Psychiatric Clinics of North America",
issn = "1056-4993",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Cytochrome P450-mediated drug interactions

AU - Flockhart, D. A.

AU - Oesterheld, J. R.

PY - 2000

Y1 - 2000

N2 - In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data.

AB - In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data.

UR - http://www.scopus.com/inward/record.url?scp=0034057966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034057966&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 43

EP - 76

JO - Child and Adolescent Psychiatric Clinics of North America

JF - Child and Adolescent Psychiatric Clinics of North America

SN - 1056-4993

IS - 1

ER -