Cytochrome P450-mediated drug interactions

D. A. Flockhart, J. R. Oesterheld

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life. To further predict and reduce the consequences of CYP-based drug interactions, child psychiatrists can limit their own formularies and review PubMed, Ovid, or other literature tracking programs each time they use two or more drugs (including nonpsychiatric ones). The following Internet websites can provide current CYP data.

Original languageEnglish (US)
Pages (from-to)43-76
Number of pages34
JournalChild and Adolescent Psychiatric Clinics of North America
Volume9
Issue number1
StatePublished - May 25 2000

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

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