Cytokines and neurodevelopmental outcomes in extremely low birth weight infants

Waldemar A. Carlo, Scott A. McDonald, Jon E. Tyson, Barbara J. Stoll, Richard A. Ehrenkranz, Seetha Shankaran, Ronald N. Goldberg, Abhik Das, Diana Schendel, Poul Thorsen, Kristin Skogstrand, David M. Hougaard, William Oh, Abbot R. Laptook, Shahnaz Duara, Avroy A. Fanaroff, Edward F. Donovan, Sheldon B. Korones, David K. Stevenson, Lu Ann PapileNeil N. Finer, T. Michael O'Shea, Brenda B. Poindexter, Linda L. Wright, Namasivayam Ambalavanan, Rosemary D. Higgins

Research output: Contribution to journalArticle

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Abstract

Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.

Original languageEnglish
JournalJournal of Pediatrics
Volume159
Issue number6
DOIs
StatePublished - Dec 2011

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Extremely Low Birth Weight Infant
Cerebral Palsy
Cytokines
Interleukin-8
Premature Infants
Tumor Necrosis Factor-alpha
Macrophage Inflammatory Proteins
Inflammation Mediators
Interleukin-17
Interleukins
Interleukin-12
Interleukin-1
Birth Weight
Interleukin-2
Anti-Inflammatory Agents
Parturition
T-Lymphocytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Carlo, W. A., McDonald, S. A., Tyson, J. E., Stoll, B. J., Ehrenkranz, R. A., Shankaran, S., ... Higgins, R. D. (2011). Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. Journal of Pediatrics, 159(6). https://doi.org/10.1016/j.jpeds.2011.05.042

Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. / Carlo, Waldemar A.; McDonald, Scott A.; Tyson, Jon E.; Stoll, Barbara J.; Ehrenkranz, Richard A.; Shankaran, Seetha; Goldberg, Ronald N.; Das, Abhik; Schendel, Diana; Thorsen, Poul; Skogstrand, Kristin; Hougaard, David M.; Oh, William; Laptook, Abbot R.; Duara, Shahnaz; Fanaroff, Avroy A.; Donovan, Edward F.; Korones, Sheldon B.; Stevenson, David K.; Papile, Lu Ann; Finer, Neil N.; O'Shea, T. Michael; Poindexter, Brenda B.; Wright, Linda L.; Ambalavanan, Namasivayam; Higgins, Rosemary D.

In: Journal of Pediatrics, Vol. 159, No. 6, 12.2011.

Research output: Contribution to journalArticle

Carlo, WA, McDonald, SA, Tyson, JE, Stoll, BJ, Ehrenkranz, RA, Shankaran, S, Goldberg, RN, Das, A, Schendel, D, Thorsen, P, Skogstrand, K, Hougaard, DM, Oh, W, Laptook, AR, Duara, S, Fanaroff, AA, Donovan, EF, Korones, SB, Stevenson, DK, Papile, LA, Finer, NN, O'Shea, TM, Poindexter, BB, Wright, LL, Ambalavanan, N & Higgins, RD 2011, 'Cytokines and neurodevelopmental outcomes in extremely low birth weight infants', Journal of Pediatrics, vol. 159, no. 6. https://doi.org/10.1016/j.jpeds.2011.05.042
Carlo WA, McDonald SA, Tyson JE, Stoll BJ, Ehrenkranz RA, Shankaran S et al. Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. Journal of Pediatrics. 2011 Dec;159(6). https://doi.org/10.1016/j.jpeds.2011.05.042
Carlo, Waldemar A. ; McDonald, Scott A. ; Tyson, Jon E. ; Stoll, Barbara J. ; Ehrenkranz, Richard A. ; Shankaran, Seetha ; Goldberg, Ronald N. ; Das, Abhik ; Schendel, Diana ; Thorsen, Poul ; Skogstrand, Kristin ; Hougaard, David M. ; Oh, William ; Laptook, Abbot R. ; Duara, Shahnaz ; Fanaroff, Avroy A. ; Donovan, Edward F. ; Korones, Sheldon B. ; Stevenson, David K. ; Papile, Lu Ann ; Finer, Neil N. ; O'Shea, T. Michael ; Poindexter, Brenda B. ; Wright, Linda L. ; Ambalavanan, Namasivayam ; Higgins, Rosemary D. / Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. In: Journal of Pediatrics. 2011 ; Vol. 159, No. 6.
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abstract = "Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.",
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AU - Carlo, Waldemar A.

AU - McDonald, Scott A.

AU - Tyson, Jon E.

AU - Stoll, Barbara J.

AU - Ehrenkranz, Richard A.

AU - Shankaran, Seetha

AU - Goldberg, Ronald N.

AU - Das, Abhik

AU - Schendel, Diana

AU - Thorsen, Poul

AU - Skogstrand, Kristin

AU - Hougaard, David M.

AU - Oh, William

AU - Laptook, Abbot R.

AU - Duara, Shahnaz

AU - Fanaroff, Avroy A.

AU - Donovan, Edward F.

AU - Korones, Sheldon B.

AU - Stevenson, David K.

AU - Papile, Lu Ann

AU - Finer, Neil N.

AU - O'Shea, T. Michael

AU - Poindexter, Brenda B.

AU - Wright, Linda L.

AU - Ambalavanan, Namasivayam

AU - Higgins, Rosemary D.

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N2 - Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.

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