Cytokines and psoriasis

When cytokines become "pathokines"

Ally-Khan Somani, M. F. Yang, K. D. Cooper, T. S. Mccormick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Psoriasis vulgaris is one of the most common autoimmune skin diseases, afflicting approximately 2-3% of the global population. The disease is characterized by erythematous plaques that constantly shed scale secondary to excessive proliferation of epidermal keratinocytes. Lesions are defined by the presence of infiltrating leukocytes including intraepidermal CD8+ T cells and neutrophils, along with epidermal acanthosis, vascular hyperplasia, and ectasia. Psoriasis is an immune-mediated disease in which genetic-susceptibility alleles and immunological and environmental factors contribute to the chronic inflammatory process incited by the interplay of infiltrating cell types and resident skin cells. There have been significant advances in our understanding of the immunopathogenesis and genetics of the disease process; however, the cause of psoriasis remains unknown and the cure still elusive. Central to the complex interplay of resident skin and immune cells are pro-inflammatory cytokines, chemokines, growth factors, and chemical mediators elaborated by cutaneous cells that direct the disease process. Given the primacy of cytokines that drive cutaneous immune responses and ultimately psoriatic plaque formation, these "pathokines" represent ideal targets for biological therapies. In this article, the crucial effector functions of cytokines in the immunological process that are central to the pathogenesis of psoriasis, and the current treatment modalities that target cytokines will be discussed.

Original languageEnglish (US)
Pages (from-to)679-690
Number of pages12
JournalGiornale Italiano di Dermatologia e Venereologia
Volume142
Issue number6
StatePublished - 2007
Externally publishedYes

Fingerprint

Psoriasis
Cytokines
Skin
Genetic Phenomena
Pathologic Dilatations
Inborn Genetic Diseases
Biological Therapy
Immune System Diseases
Immunologic Factors
Genetic Predisposition to Disease
Keratinocytes
Chemokines
Skin Diseases
Autoimmune Diseases
Hyperplasia
Blood Vessels
Intercellular Signaling Peptides and Proteins
Neutrophils
Leukocytes
Alleles

Keywords

  • Cytokines
  • Psoriasis, diagnosis
  • Psoriasis, physiopatology

ASJC Scopus subject areas

  • Dermatology

Cite this

Cytokines and psoriasis : When cytokines become "pathokines". / Somani, Ally-Khan; Yang, M. F.; Cooper, K. D.; Mccormick, T. S.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 142, No. 6, 2007, p. 679-690.

Research output: Contribution to journalArticle

Somani, A-K, Yang, MF, Cooper, KD & Mccormick, TS 2007, 'Cytokines and psoriasis: When cytokines become "pathokines"', Giornale Italiano di Dermatologia e Venereologia, vol. 142, no. 6, pp. 679-690.
Somani, Ally-Khan ; Yang, M. F. ; Cooper, K. D. ; Mccormick, T. S. / Cytokines and psoriasis : When cytokines become "pathokines". In: Giornale Italiano di Dermatologia e Venereologia. 2007 ; Vol. 142, No. 6. pp. 679-690.
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