Cytologic diagnosis of rhabdomyosarcoma in a patient with germ cell tumor: A case report

Tek Kaw Yao Tek Kaw, H. M. Cramer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The development of sarcomas in patients with germ cell tumors is rare but has been reported previously. Theories about its pathogenesis include derivation of the tumor cells from pluripotential germ cells and malignant transformation from teratomatous elements. This report describes the occurrence of rhabdomyosarcoma in a patient with a history of mixed germ cell tumor of the testis who developed a malignant pleural effusion. Cytologic evaluation of the fluid revealed single malignant cells with high nuclear/cytoplasmic ratios and prominent nucleoli. While these features initially suggested a diagnosis of metastatic seminoma, careful cytologic and immunohistochemical examination revealed features consistent with metastatic rhabdomyosarcoma. The exfoliative cytologic findings of other germ cell tumors are also discussed.

Original languageEnglish (US)
Pages (from-to)249-251
Number of pages3
JournalActa Cytologica
Volume39
Issue number2
StatePublished - Jan 1 1995

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Keywords

  • neoplasm metastasis
  • rhabdomyosarcoma, germ cells
  • testicular neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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