Cytomegalovirus but not human T lymphotropic virus type III/lymphadenopathy associated virus detected by in situ hybridisation in retinal lesions in patients with the acquired immune deficiency syndrome

P. G E Kennedy, D. A. Newsome, Jay Hess, O. Narayan, D. L. Suresch, W. R. Green, R. C. Gallo, B. F. Polk

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Paraffin sections of retinal tissue from five patients who died from the acquired immune deficiency syndrome (AIDS) and retinopathy were examined by in situ hybridisation experiments with deoxyribonucleic acid (DNA) labelled with sulphur-35 of lentivirus, human T lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV), and cytomegalovirus. HTLV-III/LAV ribonucleic acid (RNA) was not detected in any of the tissue sections. Cytomegalovirus RNA was identified, however, in three of the five patients. Retinopathy induced by cytomegalovirus may thus be one of the many syndromes potentiated by the immunosuppression caused by HTLV-III/LAV.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalBMJ (Clinical research ed.)
Volume293
Issue number6540
StatePublished - 1986
Externally publishedYes

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Cytomegalovirus
In Situ Hybridization
Acquired Immunodeficiency Syndrome
HIV
RNA
Lentivirus
Sulfur
Paraffin
Immunosuppression
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cytomegalovirus but not human T lymphotropic virus type III/lymphadenopathy associated virus detected by in situ hybridisation in retinal lesions in patients with the acquired immune deficiency syndrome. / Kennedy, P. G E; Newsome, D. A.; Hess, Jay; Narayan, O.; Suresch, D. L.; Green, W. R.; Gallo, R. C.; Polk, B. F.

In: BMJ (Clinical research ed.), Vol. 293, No. 6540, 1986, p. 162-164.

Research output: Contribution to journalArticle

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abstract = "Paraffin sections of retinal tissue from five patients who died from the acquired immune deficiency syndrome (AIDS) and retinopathy were examined by in situ hybridisation experiments with deoxyribonucleic acid (DNA) labelled with sulphur-35 of lentivirus, human T lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV), and cytomegalovirus. HTLV-III/LAV ribonucleic acid (RNA) was not detected in any of the tissue sections. Cytomegalovirus RNA was identified, however, in three of the five patients. Retinopathy induced by cytomegalovirus may thus be one of the many syndromes potentiated by the immunosuppression caused by HTLV-III/LAV.",
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