Cytomegalovirus Colitis Presenting as Hematochezia and Requiring Resection

Angel Escudero-Fabre, Oscar Cummings, James K. Kirklin, Robert C. Bourge, Joaquin S. Aldrete

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cytomegalovirus infection is one of the most prevalent viral infections affecting recipients of cardiac allografts. Of the various severe systemic manifestations, those in the gastrointestinal tract have a unique way of presenting, specifically in the colon where a process related to cytomegalovirus infection that involves all layers, with dilatation as a prominent clinical feature, has been suggested. We report herein a case of a patient with a heart allograft who had severe episodes of rejection that responded to boosting doses of steroids. Because of persistent fever, diarrhea, hematochezia, and computed tomographic findings of the abdomen that showed a highly abnormal appearance of the ascending and transverse segments of the colon, this patient subsequently underwent celiotomy. The involved segment of the colon was found to have severe inflammation with mucosal necrosis; a subtotal colectomy was done. The abundant cytomegalovirus inclusions found in the vascular endothelium of the removed damaged segment of the colon suggest that cytomegalovirus may have been a causal factor in this form of colitis. The patient recovered uneventfully.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalArchives of Surgery
Volume127
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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Gastrointestinal Hemorrhage
Colitis
Cytomegalovirus
Colon
Cytomegalovirus Infections
Allografts
Transverse Colon
Colectomy
Vascular Endothelium
Virus Diseases
Abdomen
Gastrointestinal Tract
Dilatation
Diarrhea
Fever
Necrosis
Steroids
Inflammation

ASJC Scopus subject areas

  • Surgery

Cite this

Cytomegalovirus Colitis Presenting as Hematochezia and Requiring Resection. / Escudero-Fabre, Angel; Cummings, Oscar; Kirklin, James K.; Bourge, Robert C.; Aldrete, Joaquin S.

In: Archives of Surgery, Vol. 127, No. 1, 1992, p. 102-104.

Research output: Contribution to journalArticle

Escudero-Fabre, Angel ; Cummings, Oscar ; Kirklin, James K. ; Bourge, Robert C. ; Aldrete, Joaquin S. / Cytomegalovirus Colitis Presenting as Hematochezia and Requiring Resection. In: Archives of Surgery. 1992 ; Vol. 127, No. 1. pp. 102-104.
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