Cytoreductive surgery for metastatic testis cancer: considerations of timing and extent

J. P. Donohue, Lawrence Einhorn, S. D. Williams

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We report on 26 patients who presented with widespread, massive metastatic disease from non-seminomatous germinal cell tumors of the testis. Of these 26 patients 22 (85%) are well and 21 (80%) are presumed to be cured after initial chemotherapy with platinum, vinblastine and bleomycin cytoreduction followed by secondary retroperitoneal lymph node dissection. The most critical prognostic determinant was the nature of the tissue resected. Patients with only fibrous or cystic elements and those with mature teratoma fared well. All 22 patients are well from 1 to 5 years postoperatively. However, of 9 patients with persistent cancer in the resected tissue 4 are dead and 2 other were salvaged only after extensive further chemotherapy. Of the several options available pre-treatment with 4 courses of platinum, vinblastine and bleomycin before any surgical treatment in those with massive bulk metastatic disease seems to provide the most effective cytoreduction and best survival.

Original languageEnglish
Pages (from-to)876-880
Number of pages5
JournalJournal of Urology
Volume123
Issue number6
StatePublished - 1980

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Testicular Neoplasms
Vinblastine
Bleomycin
Platinum
Drug Therapy
Teratoma
Lymph Node Excision
Testis
Neoplasms
Survival
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Cytoreductive surgery for metastatic testis cancer : considerations of timing and extent. / Donohue, J. P.; Einhorn, Lawrence; Williams, S. D.

In: Journal of Urology, Vol. 123, No. 6, 1980, p. 876-880.

Research output: Contribution to journalArticle

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