D-Cycloserine enhances durability of social skills training in autism spectrum disorder

Logan K. Wink, Noha F. Minshawi, Rebecca C. Shaffer, Martin H. Plawecki, David J. Posey, Paul S. Horn, Ryan Adams, Ernest V. Pedapati, Tori L. Schaefer, Christopher J. McDougle, Naomi Swiezy, Craig A. Erickson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. Methods: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. Results: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. Conclusions: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training.

Original languageEnglish (US)
Article number2
JournalMolecular Autism
Volume8
Issue number1
DOIs
StatePublished - Jan 25 2017

Fingerprint

Cycloserine
Placebos
Therapeutics
Autism Spectrum Disorder
Social Skills

Keywords

  • Autism
  • Autism spectrum disorder
  • d-Cycloserine
  • Social skills training

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Neuroscience
  • Developmental Biology
  • Psychiatry and Mental health

Cite this

Wink, L. K., Minshawi, N. F., Shaffer, R. C., Plawecki, M. H., Posey, D. J., Horn, P. S., ... Erickson, C. A. (2017). D-Cycloserine enhances durability of social skills training in autism spectrum disorder. Molecular Autism, 8(1), [2]. https://doi.org/10.1186/s13229-017-0116-1

D-Cycloserine enhances durability of social skills training in autism spectrum disorder. / Wink, Logan K.; Minshawi, Noha F.; Shaffer, Rebecca C.; Plawecki, Martin H.; Posey, David J.; Horn, Paul S.; Adams, Ryan; Pedapati, Ernest V.; Schaefer, Tori L.; McDougle, Christopher J.; Swiezy, Naomi; Erickson, Craig A.

In: Molecular Autism, Vol. 8, No. 1, 2, 25.01.2017.

Research output: Contribution to journalArticle

Wink, LK, Minshawi, NF, Shaffer, RC, Plawecki, MH, Posey, DJ, Horn, PS, Adams, R, Pedapati, EV, Schaefer, TL, McDougle, CJ, Swiezy, N & Erickson, CA 2017, 'D-Cycloserine enhances durability of social skills training in autism spectrum disorder', Molecular Autism, vol. 8, no. 1, 2. https://doi.org/10.1186/s13229-017-0116-1
Wink LK, Minshawi NF, Shaffer RC, Plawecki MH, Posey DJ, Horn PS et al. D-Cycloserine enhances durability of social skills training in autism spectrum disorder. Molecular Autism. 2017 Jan 25;8(1). 2. https://doi.org/10.1186/s13229-017-0116-1
Wink, Logan K. ; Minshawi, Noha F. ; Shaffer, Rebecca C. ; Plawecki, Martin H. ; Posey, David J. ; Horn, Paul S. ; Adams, Ryan ; Pedapati, Ernest V. ; Schaefer, Tori L. ; McDougle, Christopher J. ; Swiezy, Naomi ; Erickson, Craig A. / D-Cycloserine enhances durability of social skills training in autism spectrum disorder. In: Molecular Autism. 2017 ; Vol. 8, No. 1.
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abstract = "Background: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. Methods: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. Results: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. Conclusions: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training.",
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AU - Posey, David J.

AU - Horn, Paul S.

AU - Adams, Ryan

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AU - McDougle, Christopher J.

AU - Swiezy, Naomi

AU - Erickson, Craig A.

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AB - Background: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. Methods: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. Results: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. Conclusions: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training.

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