D-Dimer concentrations in normal pregnancy: New dignostic threshold are need

Jeffrey Kline, Ginger W. Williams, Jackeline Hernandez-Nino

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Background: Pregnancy is known to increase the D-dimer concentration above the conventional normal threshold of 0.50 mg/L, leading to an increased false-positive D-dimer test when venous thromboembolism (VTE) is clinically suspected in a pregnant patient. Our aim was to determine the effect of normal pregnancy on the D-dimer concentration. Methods: Healthy women who were seeking to become pregnant and had no preexisting condition known to increase the D-dimer concentration were identified. Quantitative D-dimer measurements (MDA turbidimetric assay) and fibrinogen assays were performed before conception, at each trimester, and at 4 weeks postpartum. Patients were excluded for fetal loss or preeclampsia. Results: A total of 50 women were enrolled in the study, and blood samples were obtained at preconception and all trimesters from 23 women. The mean (SD) preconception D-dimer concentration was 0.43 (0.49) mg/L, and 79% of women had a D-dimer concentration

Original languageEnglish (US)
Pages (from-to)825-829
Number of pages5
JournalClinical Chemistry
Volume51
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

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Pregnancy
Assays
Preexisting Condition Coverage
Venous Thromboembolism
Pre-Eclampsia
fibrin fragment D
Fibrinogen
Postpartum Period
Blood

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

D-Dimer concentrations in normal pregnancy : New dignostic threshold are need. / Kline, Jeffrey; Williams, Ginger W.; Hernandez-Nino, Jackeline.

In: Clinical Chemistry, Vol. 51, No. 5, 05.2005, p. 825-829.

Research output: Contribution to journalArticle

Kline, Jeffrey ; Williams, Ginger W. ; Hernandez-Nino, Jackeline. / D-Dimer concentrations in normal pregnancy : New dignostic threshold are need. In: Clinical Chemistry. 2005 ; Vol. 51, No. 5. pp. 825-829.
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