D-MEF2: A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis

Brenda Lilly, Samuel Galewsky, Anthony Firulli, Robert A. Schulz, Eric N. Olson

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

The myocyte enhancer factor (MEF) 2 family of transcription factors has been implicated in the regulation of muscle transcription in vertebrates. We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum- response factor) domains of the vertebrate MEF2 proteins. D-mef2 gene expression is first detected during Drosophila embryogenesis within mesodermal precursor cells prior to specification of the somatic and visceral muscle lineages. Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development. D-mef2 expression precedes that of the MyoD homologue, nautilus, and, in contrast to nautilus, D-mef2 appears to be expressed in all somatic and visceral muscle cell precursors. Its temporal and spatial expression patterns suggest that D- mef2 may play an important role in commitment of mesoderm to myogenic lineages.

Original languageEnglish (US)
Pages (from-to)5662-5666
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number12
DOIs
StatePublished - Jun 7 1994
Externally publishedYes

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Nautilus
MEF2 Transcription Factors
Cell Lineage
Mesoderm
Muscle Cells
Drosophila
Embryonic Development
Vertebrates
Transcription Factors
Serum Response Factor
Muscles
Muscle Development
Homeobox Genes
Myoblasts
Snails
Gene Expression
Amino Acids

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

D-MEF2 : A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis. / Lilly, Brenda; Galewsky, Samuel; Firulli, Anthony; Schulz, Robert A.; Olson, Eric N.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 12, 07.06.1994, p. 5662-5666.

Research output: Contribution to journalArticle

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