Daily sequential changes in plasma atrial natriuretic factor concentrations in mechanically ventilated low-birth-weight infants

Effect of surfactant replacement

Edward A. Liechty, Michael D. Johnson, David Z. Myerberg, Martha D. Mullett

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Plasma atrial natriuretic factor (ANF) concentrations are elevated in mechanically ventilated infants. To test the hypothesis that changes in pulmonary compliance affect ANF cncentration, we measured plasma ANF concentrations sequentially in low-birth-weight, ventilated infants who either received surfactant replacement or placebo on day 1. ANF concentrations were elevated as compared to adult controls on day 1 and increased significantly on days 2 and 3 before declining. Day 5 concentrations were not different from day 1. Several infants had ANF concentrations greater than 1,280 pg/ml on days 2-4. There were no significant differences in ANF concentrations between surfactant-treated and non-treated infants on any day. ANF concentrations increased in parallel with changes in salt and water balance, but no significant relationships were apparent between absolute ANF concentrations and parameters of salt and water balance. The results suggest that ANF secretion is elevated in infants with pulmonary disease. While the temporal relationship between the initial rise in ANF concentration and increase in salt and water excretion suggest that ANF is involved in this diuresis, the role it may play is unclear from the present data.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalNeonatology
Volume55
Issue number4-5
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Low Birth Weight Infant
Atrial Natriuretic Factor
Surface-Active Agents
Salts
Water
Lung Compliance
Diuresis
Lung Diseases
Placebos

Keywords

  • Atrial natriuretic peptide
  • Respiratory distress syndrome
  • Surfactant

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Daily sequential changes in plasma atrial natriuretic factor concentrations in mechanically ventilated low-birth-weight infants : Effect of surfactant replacement. / Liechty, Edward A.; Johnson, Michael D.; Myerberg, David Z.; Mullett, Martha D.

In: Neonatology, Vol. 55, No. 4-5, 1989, p. 244-250.

Research output: Contribution to journalArticle

Liechty, Edward A. ; Johnson, Michael D. ; Myerberg, David Z. ; Mullett, Martha D. / Daily sequential changes in plasma atrial natriuretic factor concentrations in mechanically ventilated low-birth-weight infants : Effect of surfactant replacement. In: Neonatology. 1989 ; Vol. 55, No. 4-5. pp. 244-250.
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