Daily supplementation with 25 μg cholecalciferol does not increase calcium absorption or skeletal retention in adolescent girls with low serum 25-hydroxyvitamin D

Clara Y. Park, Kathleen M. Hill, Ann E. Elble, Berdine R. Martin, Linda A. DiMeglio, Munro Peacock, George P. McCabe, Connie M. Weaver

Research output: Contribution to journalArticle

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Abstract

In healthy adolescents, cross-sectional studies show either no or negative relationships between serum 25-hydroxyvitamin D [25(OH)D] and calcium (Ca) absorption. Using a 2-period metabolic balance study, the effect of vitamin D supplementation on Ca absorption and retention in adolescent girls was investigated. Eleven girls aged 12-14 y with a mean entry serum 25(OH)D of 35.1 nmol/L consumed a controlled intake (providing 5 mg vitamin D and 1117 mg Ca/d) for two 3-wk metabolic balance periods separated by a 1-wk washout period. Sunlight exposure was minimized by sunscreen with a sun protection factor ≥ 15. After the first metabolic balance period, participants received 25 μg/d cholecalciferol supplementation for 4 wk. Fractional Ca absorption was measured in each metabolic balance period using a stable Ca isotope method. All urine and fecal samples were collected and analyzed to measure net Ca absorption and Ca retention. Paired t tests and correlations were used to analyze the data. Daily supplementation with 25 μg vitamin D resulted in a mean increase in serum 25(OH)D of 13.3 nmol/L (P< 0.01) but a decrease in fractional Ca absorption of 8.3% (P< 0.05) and no significant change in fasting serum 1,25-dihydroxyvitamin D, parathyroid hormone, net Ca absorption, or Ca skeletal retention. In pubertal girls with vitamin D status considered insufficient in adults, vitamin D supplementation of 25 μg/d for 4 wk did not improve fractional Ca absorption, net Ca absorption, or Ca retention.

Original languageEnglish (US)
Pages (from-to)2139-2144
Number of pages6
JournalJournal of Nutrition
Volume140
Issue number12
DOIs
StatePublished - Dec 1 2010

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Cholecalciferol
Calcium
Serum
Vitamin D
Calcium Isotopes
25-hydroxyvitamin D
Sun Protection Factor
Sunscreening Agents
Sunlight
Parathyroid Hormone
Fasting
Cross-Sectional Studies
Urine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Daily supplementation with 25 μg cholecalciferol does not increase calcium absorption or skeletal retention in adolescent girls with low serum 25-hydroxyvitamin D. / Park, Clara Y.; Hill, Kathleen M.; Elble, Ann E.; Martin, Berdine R.; DiMeglio, Linda A.; Peacock, Munro; McCabe, George P.; Weaver, Connie M.

In: Journal of Nutrition, Vol. 140, No. 12, 01.12.2010, p. 2139-2144.

Research output: Contribution to journalArticle

Park, Clara Y. ; Hill, Kathleen M. ; Elble, Ann E. ; Martin, Berdine R. ; DiMeglio, Linda A. ; Peacock, Munro ; McCabe, George P. ; Weaver, Connie M. / Daily supplementation with 25 μg cholecalciferol does not increase calcium absorption or skeletal retention in adolescent girls with low serum 25-hydroxyvitamin D. In: Journal of Nutrition. 2010 ; Vol. 140, No. 12. pp. 2139-2144.
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