Data mining in brain imaging

V. Megalooikonomou, J. Ford, L. Shen, F. Makedon, A. Saykin

Research output: Contribution to journalReview article

58 Scopus citations


Data mining in brain imaging is proving to be an effective methodology for disease prognosis and prevention. This, together with the rapid accumulation of massive heterogeneous data sets, motivates the need for efficient methods that filter, clarify, assess, correlate and cluster brain-related information. Here, we present data mining methods that have been or could be employed in the analysis of brain images. These methods address two types of brain imaging data: structural and functional. We introduce statistical methods that aid the discovery of interesting associations and patterns between brain images and other clinical data. We consider several applications of these methods, such as the analysis of task-activation, lesion-deficit, and structure morphological variability; the development of probabilistic atlases; and tumour analysis. We include examples of applications to real brain data. Several data mining issues, such as that of method validation or verification, are also discussed.

Original languageEnglish (US)
Pages (from-to)359-394
Number of pages36
JournalStatistical Methods in Medical Research
Issue number4
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

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