Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya

Anne E P Frosch, Bartholomew N. Ondigo, George A. Ayodo, John M. Vulule, Chandy John, Sarah E. Cusick

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Achieving optimal iron status in children in malariaendemic areas may increase the risk of malaria. Malaria itself may contribute to iron deficiency, but the impact of an interruption in malaria transmission on the prevalence of iron deficiency is unknown. Objectives: We aimed to determine whether 1) iron status improved in children living in 2 Kenyan villages with a documented cessation in malaria transmission and 2) changes in iron status correlated with changes in hemoglobin. Design: We measured iron [hemoglobin, ferritin, soluble transferrin receptor (sTfR)] and inflammatory [C-reactive protein (CRP)] markers in paired plasma samples from 190 children aged 4-59 mo at the beginning (May 2007) and end (July 2008) of a documented 12-mo period of interruption in malaria transmission in 2 highland areas in Kenya with unstable malaria transmission and ongoing malaria surveillance. Results: Between May 2007 and July 2008, mean (±SD) hemoglobin increased from 10.8 ± 1.6 to 11.6 ± 1.6 g/dL. Median (25th, 75th percentile) ferritin increased from 17.0 (9.7, 25.6) to 22.6 (13.4, 34.7) μg/L (P <0.001), whereas median sTfR decreased from 32.4 (26.3, 43.2) to 27.7 (22.1, 36.0) nmol/L (P <0.001). Median CRP was low (

Original languageEnglish (US)
Pages (from-to)968-973
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume100
Issue number3
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

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Kenya
Malaria
Iron
Hemoglobins
Transferrin Receptors
Ferritins
C-Reactive Protein

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. / Frosch, Anne E P; Ondigo, Bartholomew N.; Ayodo, George A.; Vulule, John M.; John, Chandy; Cusick, Sarah E.

In: American Journal of Clinical Nutrition, Vol. 100, No. 3, 01.09.2014, p. 968-973.

Research output: Contribution to journalArticle

Frosch, Anne E P ; Ondigo, Bartholomew N. ; Ayodo, George A. ; Vulule, John M. ; John, Chandy ; Cusick, Sarah E. / Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. In: American Journal of Clinical Nutrition. 2014 ; Vol. 100, No. 3. pp. 968-973.
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