Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder

Zaiyang Long, Carla Medlock, Mario Dzemidzic, Yong Wook Shin, Andrew W. Goddard, Ulrike Dydak

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Changes of various brain metabolites including γ-aminobutyric acid (GABA), measured by 1H-magnetic resonance spectroscopy (MRS), have been reported in panic disorder (PD). Deficits in GABA have been implicated in the pathophysiology of PD. Furthermore, it has been suggested that cortical metabolite changes in PD are familial. Eleven PD patients, including five with and six without a PD family history, and eight age- and gender-matched healthy controls without a family history of psychopathology were recruited. Each subject underwent MRS exams and behavioral assessments (resting visual analog anxiety level and the Panic Disorder Severity Scale). GABA was detected with a MEGA-PRESS J-editing sequence and fitted to minimize macromolecule contaminations. A significant decrease in GABA, expressed as the ratio of GABA over total creatine (GABA/tCr), was detected in the anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) in PD patients (p. <0.05), which tends to be pronounced in patients with a PD family history. No other patient/control differences in metabolites were noted in the ACC/mPFC or occipital cortex (OCC). Overall, our results indicate that deficits in GABA levels in PD patients vary by brain regions and possibly by family history status.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume44
DOIs
StatePublished - Jul 1 2013

Fingerprint

Panic Disorder
Gyrus Cinguli
Prefrontal Cortex
gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Aminobutyrates
Occipital Lobe
Creatine
Brain
Psychopathology
Anxiety

Keywords

  • Family history
  • GABA
  • MRS
  • Panic disorder

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder. / Long, Zaiyang; Medlock, Carla; Dzemidzic, Mario; Shin, Yong Wook; Goddard, Andrew W.; Dydak, Ulrike.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 44, 01.07.2013, p. 131-135.

Research output: Contribution to journalArticle

Long, Zaiyang ; Medlock, Carla ; Dzemidzic, Mario ; Shin, Yong Wook ; Goddard, Andrew W. ; Dydak, Ulrike. / Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013 ; Vol. 44. pp. 131-135.
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