Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis

P. Y. Ong, Q. A. Hamid, J. B. Travers, I. Strickland, M. Al Kerithy, M. Boguniewicz, D. Y.M. Leung

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34 Scopus citations


PBMC and acute skin lesions of patients with atopic dermatitis (AD) are characterized by increased IL-4 and IL-13, but decreased IFN-γ production. This bias toward an increased Th2 cytokine profile may contribute to the elevated IgE levels and acute skin inflammation seen in AD. In this study, we examined the levels of IL-15, a Th1-like cytokine, in the PBMC and the skin lesions of AD patients. IL-15 secretion by Staphylococcal enterotoxin B-treated PBMC of AD patients was significantly lower than that of normals and psoriasis patients (p < 0.001). Membrane-bound IL-15 expression as measured by mean fluorescence intensity and percentage of IL-15-positive cells in Staphylococcal enterotoxin B-treated monocytes of AD patients (644 ± 49% and 12.7 ± 0.6%, respectively) were significantly lower than that of normals (869 ± 56% and 15.8 ± 1.2%, respectively) and psoriasis patients (1488 ± 217% and 22.7 ± 0.8%, respectively; p < 0.0007 and p < 0.0001, respectively). The membrane-bound IL-15 expression was also significantly lower in the control monocytes of AD patients compared with that in normals and psoriasis patients. There was no significant difference in the absolute number or percentage of monocytes between the study subjects. However, psoriasis skin lesions were found to have significantly more IL-15 mRNA-expressing cells (22.4 ± 1.7) compared with that in acute AD (7.5 ± 1.7) and chronic AD (13.7 ± 1.7) skin lesions (p < 0.05). IL-15 enhanced IFN-γ production by the PBMC of AD patients (p < 0.01), but not by that of normal individuals or psoriasis patients. In addition, IL-15 was found to suppress IgE synthesis (p < 0.01) by the PBMC of AD patients. These data support the concept that reduced IL-15 expression may contribute to the pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)505-510
Number of pages6
JournalJournal of Immunology
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Ong, P. Y., Hamid, Q. A., Travers, J. B., Strickland, I., Al Kerithy, M., Boguniewicz, M., & Leung, D. Y. M. (2002). Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. Journal of Immunology, 168(1), 505-510.