Decreased levels of soluble amyloid β-protein precursor are associated with Alzheimer's disease in concordant and discordant monozygous twin pairs

Steven L. Wagner, Elaine R. Peskind, David Nochlin, Sally Provow, Jeffrey S. Farrow, M. R. Pandian, Michelle Cleveland, Ralph K. Ito, Martin Farlow

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We conducted immunochemical measurements of soluble amyloid β-protein precursor (βPP) in cerebrospinal fluid (CSF) from three monozygous twin pairs. Two of the twin pairs are discordant for Alzheimer's disease and one pair showed concordance for Alzheimer's disease, which was confirmed neuropathologically. All affected individuals displayed substantially lower levels of soluble βPP in CSF compared with the unaffected individuals. There were no differences in total protein levels in CSF samples from the affected twins compared with those of the unaffected twins. These studies suggest that decreased soluble βPP in CSF may reflect neuropathological processes in Alzheimer's disease involving βPP.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalAnnals of Neurology
Volume36
Issue number2
DOIs
StatePublished - Aug 1994

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Amyloid beta-Protein Precursor
Protein Precursors
Cerebrospinal Fluid
Alzheimer Disease
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

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Decreased levels of soluble amyloid β-protein precursor are associated with Alzheimer's disease in concordant and discordant monozygous twin pairs. / Wagner, Steven L.; Peskind, Elaine R.; Nochlin, David; Provow, Sally; Farrow, Jeffrey S.; Pandian, M. R.; Cleveland, Michelle; Ito, Ralph K.; Farlow, Martin.

In: Annals of Neurology, Vol. 36, No. 2, 08.1994, p. 215-220.

Research output: Contribution to journalArticle

Wagner, Steven L. ; Peskind, Elaine R. ; Nochlin, David ; Provow, Sally ; Farrow, Jeffrey S. ; Pandian, M. R. ; Cleveland, Michelle ; Ito, Ralph K. ; Farlow, Martin. / Decreased levels of soluble amyloid β-protein precursor are associated with Alzheimer's disease in concordant and discordant monozygous twin pairs. In: Annals of Neurology. 1994 ; Vol. 36, No. 2. pp. 215-220.
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