Decreased plasma fibronectin in neonatal sepsis

J. S. Gerdes, M. C. Yoder, S. D. Douglas, R. A. Polin

Research output: Contribution to journalArticle

36 Scopus citations


Fibronectin is a large opsonic glycoprotein which promotes reticuloendothelial system clearance of bacteria, immune complexes, collagenous debris, and damaged platelets. The concentration of plasma fibronectin is decreased in the newborn infant; however, the role of fibronectin in the onset and course of neonatal sepsis is unknown. Serial plasma fibronectin levels were determined in 19 neonates with documented bacterial sepsis. Plasma fibronectin concentrations decreased significantly (P<.001) in all study infants concurrent with the development of septicemia. Recovery of plasma fibronectin to normal levels occurred by day 5 in premature neonates and by days 7 to 10 in term neonates. Fibronectin deficiency and resultant reticuloendothelial system impairment may decrease the ability of newborn infants to resist or clear bacterial infections. An acute reduction in the concentration of plasma fibronectin may be a valuable marker for neonatal sepsis.

Original languageEnglish (US)
Pages (from-to)877-881
Number of pages5
Issue number6
StatePublished - Dec 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Gerdes, J. S., Yoder, M. C., Douglas, S. D., & Polin, R. A. (1983). Decreased plasma fibronectin in neonatal sepsis. Pediatrics, 72(6), 877-881.