Decreasing deceased donor transplant rates among children (≤6 years) under the new kidney allocation system

Brittany A. Shelton, Deirdre Sawinski, Christopher Ray, Rhiannon D. Reed, Paul A. MacLennan, Justin Blackburn, Carlton J. Young, Stephen Gray, Megan Yanik, Allan Massie, Dorry L. Segev, Jayme E. Locke

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The Kidney Allocation System (KAS) was implemented in December 2014 with unknown impact on the pediatric waitlist. To understand the effect of KAS on pediatric registrants, deceased donor kidney transplant (DDKT) rate was assessed using interrupted time series analysis and time-to-event analysis. Two allocation eras were defined with an intermediary washout period: Era 1 (01/01/2013-09/01/2014), Era 2 (09/01/2014-03/01/2015), and Era 3(03/01/2015-03/01/2017). When using Cox proportional hazards, there was no significant association between allocation era and DDKT likelihood as compared to Era 1 (Era 3: aHR: 1.07, 95% CI: 0.97-1.18, P =.17). However, this was not consistent across all subgroups. Specifically, while highly sensitized pediatric registrants were consistently less likely to be transplanted than their less sensitized counterparts, this disparity was attenuated in Era 3 (Era 1 aHR: 0.04, 95%CI: 0.01-0.14, P <.001; Era 3 aHR: 0.33, 95% CI: 0.21-0.53, P <.001) whereas the youngest registrants aged 0-6 experienced a 21% decrease in DDKT likelihood in Era 3 as compared to Era 1 (aHR: 0.79, 95% CI: 0.64-0.98, P =.03). Thus, while overall DDKT likelihood remained stable with the introduction of KAS, registrants ≤ 6 years of age were disadvantaged, warranting further study to ensure equitable access to transplantation.

Original languageEnglish (US)
Pages (from-to)1690-1698
Number of pages9
JournalAmerican Journal of Transplantation
Volume18
Issue number7
DOIs
StatePublished - Jul 2018
Externally publishedYes

Keywords

  • health services and outcomes research
  • kidney transplantation/nephrology
  • organ allocation
  • patient survival

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Shelton, B. A., Sawinski, D., Ray, C., Reed, R. D., MacLennan, P. A., Blackburn, J., Young, C. J., Gray, S., Yanik, M., Massie, A., Segev, D. L., & Locke, J. E. (2018). Decreasing deceased donor transplant rates among children (≤6 years) under the new kidney allocation system. American Journal of Transplantation, 18(7), 1690-1698. https://doi.org/10.1111/ajt.14663