Deep vein thrombosis and pulmonary embolism in cirrhotic patients

Systematic review

Ashish Aggarwal, Kanika Puri, Suthat Liangpunsakul

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Patients with liver cirrhosis were traditionally believed to be protected against development of blood clots. Lately, studies have shown that these patients may probably be at an increased risk of venous thrombotic complications. Although the hemostatic changes in the chronic liver disease patients and the factors that may predict bleeding vs thrombotic complications remains an area of active research, it is believed that the coagulation cascade is delicately balanced in these patients because of parallel reduced hepatic synthesis of pro and anticoagulant factors. Thrombotic state in cirrhotic patients is responsible for not only portal or non-portal thrombosis [deep vein thrombosis (DVT) and pulmonary embolism (PE)]; it has also been associated with progression of liver fibrosis. The use of anticoagulants in cirrhosis patients is a challenging, and often a scary situation. This review summarizes the current literature on the prevalence of venous thrombosis (DVT and PE), risk factors and safety of prophylactic and therapeutic anticoagulation in patients with chronic liver disease.

Original languageEnglish
Pages (from-to)5737-5745
Number of pages9
JournalWorld Journal of Gastroenterology
Volume20
Issue number19
DOIs
StatePublished - 2014

Fingerprint

Pulmonary Embolism
Venous Thrombosis
Liver Cirrhosis
Anticoagulants
Liver Diseases
Thrombosis
Chronic Disease
Hemostatics
Fibrosis
Hemorrhage
Safety
Liver
Research

Keywords

  • Anticoagulation
  • Chronic liver disease
  • Cirrhosis
  • Deep venous thrombosis
  • Pathogenesis
  • Portal vein thrombosis
  • Thrombosis

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Deep vein thrombosis and pulmonary embolism in cirrhotic patients : Systematic review. / Aggarwal, Ashish; Puri, Kanika; Liangpunsakul, Suthat.

In: World Journal of Gastroenterology, Vol. 20, No. 19, 2014, p. 5737-5745.

Research output: Contribution to journalArticle

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