Defining failure and its predictors in mandibular distraction for Robin sequence

Roberto L. Flores, S. Travis Greathouse, Melinda Costa, Youssef Tahiri, Tahereh Soleimani, Sunil S. Tholpady

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction Robin sequence (RS) is defined as the triad of micrognathia, glossoptosis and airway obstruction. A popular surgical treatment is mandibular distraction osteogenesis (MDO). In this study, it is demonstrated that the associated variables change, dependent on the manner in which failure is defined. These multiple failure outcomes are used to construct a scoring system to predict MDO failure. Methods A retrospective database of neonatal MDO patients was constructed. Failure outcomes studied included tracheostomy; a decrease in the apnea-hypopnea index (AHI) but an AHI >20; and death. A combination of bivariate and regression analysis was used to produce significantly associated variables and a scoring system. Results Statistical analysis demonstrated the association of gastroesophageal reflux; age >30 days; neurologic anomaly; airway anomalies, other than laryngomalacia; an intact palate; and pre-operative intubation on the outcome variables studied. Multiple scoring systems were produced with reasonable sensitivity, specificity, and positive and negative predictive value. Conclusions When reporting surgical outcomes of MDO in the setting of RS, it is important to consider the AHI as well as avoidance of tracheostomy as an outcome variable. Incomplete amelioration of AHI accounts for half of the patients with a problem after MDO. The predictive scores presented will be used and validated on a larger, prospectively collected dataset.

Original languageEnglish
Pages (from-to)1614-1619
Number of pages6
JournalJournal of Cranio-Maxillofacial Surgery
Volume43
Issue number8
DOIs
StatePublished - Oct 1 2015

Fingerprint

Pierre Robin Syndrome
Distraction Osteogenesis
Apnea
Tracheostomy
Micrognathism
Laryngomalacia
Nervous System Malformations
Palate
Airway Obstruction
Gastroesophageal Reflux
Intubation
Regression Analysis
Databases
Sensitivity and Specificity

Keywords

  • Avoidance of tracheostomy
  • Mandibular distraction osteogenesis
  • Pierre Robin sequence
  • Predictors of failure

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

Cite this

Flores, R. L., Greathouse, S. T., Costa, M., Tahiri, Y., Soleimani, T., & Tholpady, S. S. (2015). Defining failure and its predictors in mandibular distraction for Robin sequence. Journal of Cranio-Maxillofacial Surgery, 43(8), 1614-1619. https://doi.org/10.1016/j.jcms.2015.06.039

Defining failure and its predictors in mandibular distraction for Robin sequence. / Flores, Roberto L.; Greathouse, S. Travis; Costa, Melinda; Tahiri, Youssef; Soleimani, Tahereh; Tholpady, Sunil S.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 43, No. 8, 01.10.2015, p. 1614-1619.

Research output: Contribution to journalArticle

Flores, RL, Greathouse, ST, Costa, M, Tahiri, Y, Soleimani, T & Tholpady, SS 2015, 'Defining failure and its predictors in mandibular distraction for Robin sequence', Journal of Cranio-Maxillofacial Surgery, vol. 43, no. 8, pp. 1614-1619. https://doi.org/10.1016/j.jcms.2015.06.039
Flores, Roberto L. ; Greathouse, S. Travis ; Costa, Melinda ; Tahiri, Youssef ; Soleimani, Tahereh ; Tholpady, Sunil S. / Defining failure and its predictors in mandibular distraction for Robin sequence. In: Journal of Cranio-Maxillofacial Surgery. 2015 ; Vol. 43, No. 8. pp. 1614-1619.
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