Defining human endothelial progenitor cells

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

There is no specific marker to identify an endothelial progenitor cell (EPC) and this deficiency is restricting the ability of an entire field of research in defining these cells. We will review current methods to define EPC in the human system and suggest approaches to define better the cell populations involved in neoangiogenesis. PubMed was used to identify articles via the search term 'endothelial progenitor cell' and those articles focused on defining the term were evaluated. The only human cells expressing the characteristics of an EPC, as originally proposed, are endothelial colony forming cells. A variety of hematopoietic cells including stem and progenitors, participate in initiating and modulating neoangiogenesis. Future studies must focus on defining the specific hematopoietic subsets that are involved in activating, recruiting, and remodeling the vascular networks formed by the endothelial colony forming cells.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue numberSUPPL. 1
DOIs
StatePublished - 2009

Fingerprint

Hematopoietic Stem Cells
PubMed
Endothelial Progenitor Cells
Research
Population
Vascular Remodeling

Keywords

  • Endothelial colony forming cells
  • Endothelial progenitor cells
  • Hematopoietic progenitor cells
  • Neoangiogenesis

ASJC Scopus subject areas

  • Hematology

Cite this

Defining human endothelial progenitor cells. / Yoder, Mervin.

In: Journal of Thrombosis and Haemostasis, Vol. 7, No. SUPPL. 1, 2009, p. 49-52.

Research output: Contribution to journalArticle

@article{0c37cd491716469587567cb0f4b87830,
title = "Defining human endothelial progenitor cells",
abstract = "There is no specific marker to identify an endothelial progenitor cell (EPC) and this deficiency is restricting the ability of an entire field of research in defining these cells. We will review current methods to define EPC in the human system and suggest approaches to define better the cell populations involved in neoangiogenesis. PubMed was used to identify articles via the search term 'endothelial progenitor cell' and those articles focused on defining the term were evaluated. The only human cells expressing the characteristics of an EPC, as originally proposed, are endothelial colony forming cells. A variety of hematopoietic cells including stem and progenitors, participate in initiating and modulating neoangiogenesis. Future studies must focus on defining the specific hematopoietic subsets that are involved in activating, recruiting, and remodeling the vascular networks formed by the endothelial colony forming cells.",
keywords = "Endothelial colony forming cells, Endothelial progenitor cells, Hematopoietic progenitor cells, Neoangiogenesis",
author = "Mervin Yoder",
year = "2009",
doi = "10.1111/j.1538-7836.2009.03407.x",
language = "English",
volume = "7",
pages = "49--52",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Defining human endothelial progenitor cells

AU - Yoder, Mervin

PY - 2009

Y1 - 2009

N2 - There is no specific marker to identify an endothelial progenitor cell (EPC) and this deficiency is restricting the ability of an entire field of research in defining these cells. We will review current methods to define EPC in the human system and suggest approaches to define better the cell populations involved in neoangiogenesis. PubMed was used to identify articles via the search term 'endothelial progenitor cell' and those articles focused on defining the term were evaluated. The only human cells expressing the characteristics of an EPC, as originally proposed, are endothelial colony forming cells. A variety of hematopoietic cells including stem and progenitors, participate in initiating and modulating neoangiogenesis. Future studies must focus on defining the specific hematopoietic subsets that are involved in activating, recruiting, and remodeling the vascular networks formed by the endothelial colony forming cells.

AB - There is no specific marker to identify an endothelial progenitor cell (EPC) and this deficiency is restricting the ability of an entire field of research in defining these cells. We will review current methods to define EPC in the human system and suggest approaches to define better the cell populations involved in neoangiogenesis. PubMed was used to identify articles via the search term 'endothelial progenitor cell' and those articles focused on defining the term were evaluated. The only human cells expressing the characteristics of an EPC, as originally proposed, are endothelial colony forming cells. A variety of hematopoietic cells including stem and progenitors, participate in initiating and modulating neoangiogenesis. Future studies must focus on defining the specific hematopoietic subsets that are involved in activating, recruiting, and remodeling the vascular networks formed by the endothelial colony forming cells.

KW - Endothelial colony forming cells

KW - Endothelial progenitor cells

KW - Hematopoietic progenitor cells

KW - Neoangiogenesis

UR - http://www.scopus.com/inward/record.url?scp=67849095429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849095429&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2009.03407.x

DO - 10.1111/j.1538-7836.2009.03407.x

M3 - Article

VL - 7

SP - 49

EP - 52

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - SUPPL. 1

ER -