Definition, evaluation, and classification of renal osteodystrophy

A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)

Sharon Moe, T. Drüeke, J. Cunningham, W. Goodman, K. Martin, K. Olgaard, S. Ott, S. Sprague, N. Lameire, G. Eknoyan

Research output: Contribution to journalArticle

1101 Citations (Scopus)

Abstract

Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified based on bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) sponsored a Controversies Conference on Renal Osteodystrophy to (1) develop a clear, clinically relevant, and internationally acceptable definition and classification system, (2) develop a consensus for bone biopsy evaluation and classification, and (3) evaluate laboratory and imaging markers for the clinical assessment of patients with CKD. It is recommended that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, which can be further assessed by histomorphometry, and the results reported based on a unified classification system that includes parameters of turnover, mineralization, and volume, and (2) the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and mineral metabolism and/or extra-skeletal calcification. The international adoption of these recommendations will greatly enhance communication, facilitate clinical decision-making, and promote the evolution of evidence-based clinical practice guidelines worldwide.

Original languageEnglish
Pages (from-to)1945-1953
Number of pages9
JournalKidney International
Volume69
Issue number11
DOIs
StatePublished - Jun 2006

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
Kidney Diseases
Chronic Renal Insufficiency
Bone and Bones
Minerals
Biopsy
Evidence-Based Practice
Practice Guidelines
Consensus
Biomarkers
Communication
Quality of Life
Morbidity
Mortality

Keywords

  • Bone biopsy
  • Chronic kidney disease
  • Chronic renal failure
  • Renal osteodystrophy
  • Uremia
  • Vascular calcification

ASJC Scopus subject areas

  • Nephrology

Cite this

Definition, evaluation, and classification of renal osteodystrophy : A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). / Moe, Sharon; Drüeke, T.; Cunningham, J.; Goodman, W.; Martin, K.; Olgaard, K.; Ott, S.; Sprague, S.; Lameire, N.; Eknoyan, G.

In: Kidney International, Vol. 69, No. 11, 06.2006, p. 1945-1953.

Research output: Contribution to journalArticle

Moe, S, Drüeke, T, Cunningham, J, Goodman, W, Martin, K, Olgaard, K, Ott, S, Sprague, S, Lameire, N & Eknoyan, G 2006, 'Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)', Kidney International, vol. 69, no. 11, pp. 1945-1953. https://doi.org/10.1038/sj.ki.5000414
Moe, Sharon ; Drüeke, T. ; Cunningham, J. ; Goodman, W. ; Martin, K. ; Olgaard, K. ; Ott, S. ; Sprague, S. ; Lameire, N. ; Eknoyan, G. / Definition, evaluation, and classification of renal osteodystrophy : A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). In: Kidney International. 2006 ; Vol. 69, No. 11. pp. 1945-1953.
@article{0914575e3f894805a040c72050d88848,
title = "Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)",
abstract = "Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified based on bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) sponsored a Controversies Conference on Renal Osteodystrophy to (1) develop a clear, clinically relevant, and internationally acceptable definition and classification system, (2) develop a consensus for bone biopsy evaluation and classification, and (3) evaluate laboratory and imaging markers for the clinical assessment of patients with CKD. It is recommended that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, which can be further assessed by histomorphometry, and the results reported based on a unified classification system that includes parameters of turnover, mineralization, and volume, and (2) the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and mineral metabolism and/or extra-skeletal calcification. The international adoption of these recommendations will greatly enhance communication, facilitate clinical decision-making, and promote the evolution of evidence-based clinical practice guidelines worldwide.",
keywords = "Bone biopsy, Chronic kidney disease, Chronic renal failure, Renal osteodystrophy, Uremia, Vascular calcification",
author = "Sharon Moe and T. Dr{\"u}eke and J. Cunningham and W. Goodman and K. Martin and K. Olgaard and S. Ott and S. Sprague and N. Lameire and G. Eknoyan",
year = "2006",
month = "6",
doi = "10.1038/sj.ki.5000414",
language = "English",
volume = "69",
pages = "1945--1953",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Definition, evaluation, and classification of renal osteodystrophy

T2 - A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)

AU - Moe, Sharon

AU - Drüeke, T.

AU - Cunningham, J.

AU - Goodman, W.

AU - Martin, K.

AU - Olgaard, K.

AU - Ott, S.

AU - Sprague, S.

AU - Lameire, N.

AU - Eknoyan, G.

PY - 2006/6

Y1 - 2006/6

N2 - Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified based on bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) sponsored a Controversies Conference on Renal Osteodystrophy to (1) develop a clear, clinically relevant, and internationally acceptable definition and classification system, (2) develop a consensus for bone biopsy evaluation and classification, and (3) evaluate laboratory and imaging markers for the clinical assessment of patients with CKD. It is recommended that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, which can be further assessed by histomorphometry, and the results reported based on a unified classification system that includes parameters of turnover, mineralization, and volume, and (2) the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and mineral metabolism and/or extra-skeletal calcification. The international adoption of these recommendations will greatly enhance communication, facilitate clinical decision-making, and promote the evolution of evidence-based clinical practice guidelines worldwide.

AB - Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified based on bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) sponsored a Controversies Conference on Renal Osteodystrophy to (1) develop a clear, clinically relevant, and internationally acceptable definition and classification system, (2) develop a consensus for bone biopsy evaluation and classification, and (3) evaluate laboratory and imaging markers for the clinical assessment of patients with CKD. It is recommended that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, which can be further assessed by histomorphometry, and the results reported based on a unified classification system that includes parameters of turnover, mineralization, and volume, and (2) the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and mineral metabolism and/or extra-skeletal calcification. The international adoption of these recommendations will greatly enhance communication, facilitate clinical decision-making, and promote the evolution of evidence-based clinical practice guidelines worldwide.

KW - Bone biopsy

KW - Chronic kidney disease

KW - Chronic renal failure

KW - Renal osteodystrophy

KW - Uremia

KW - Vascular calcification

UR - http://www.scopus.com/inward/record.url?scp=33645757920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645757920&partnerID=8YFLogxK

U2 - 10.1038/sj.ki.5000414

DO - 10.1038/sj.ki.5000414

M3 - Article

VL - 69

SP - 1945

EP - 1953

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 11

ER -