Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina

Jinok Choi, Ann Lin, Eric Shrier, Lester F. Lau, Maria B. Grant, Brahim Chaqour

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: CCN1, a matricellular protein composed of four modular domains, is essential for proper vascular development. Results: CCN1 variants containing fewer domains stimulate or inhibit retinal neovascularization under ischemic conditions. Conclusion: Proteolytic degradation of CCN1 amplifies the angiogenic or angiostatic potential of its exposed domains. Significance: CCN1 degradation products are potential targets for therapeutic inhibition or monitoring of retinal neovascular diseases.

Original languageEnglish (US)
Pages (from-to)23075-23089
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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