Dehydroretronecine-lnduced skin tumors in mice

William D. Johnson, Kent A. Robertson, Joel G. Pounds, James R. Allen

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Female swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydro- retronecine, a metabolite of the pyrrolizidine alkaloid mono- crotaline, and were observed for 15 months for tumor development. of 92 animals examined, 63 had tumors at the site of application or injection; 47 of these had skin tumors, mainly basal cell and squamous ceil carcinomas. these data indicate that de- hydroretronecine is a proximate carcinogen capable of causing a high incidence of skin tumors in mice at the site of sc injection or topical application.—j natl cancer inst 61: 85-89, 1978.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalJournal of the National Cancer Institute
Volume61
Issue number1
DOIs
StatePublished - Jul 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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