Female swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydro- retronecine, a metabolite of the pyrrolizidine alkaloid mono- crotaline, and were observed for 15 months for tumor development. of 92 animals examined, 63 had tumors at the site of application or injection; 47 of these had skin tumors, mainly basal cell and squamous ceil carcinomas. these data indicate that de- hydroretronecine is a proximate carcinogen capable of causing a high incidence of skin tumors in mice at the site of sc injection or topical application.—j natl cancer inst 61: 85-89, 1978.
ASJC Scopus subject areas
- Cancer Research