Delayed hypersensitivity to mumps antigen in humans

John T. Callaghan, Bruce H. Petersen, Wendell C. Smith, Warren W. Epinette, Robert C. Ransburg

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Sixty-one subjects, preselected for mumps sensitivity, were entered into a double-blind protocol to standardize Mumps Skin Test Antigen. Four lots of mumps antigen selected on the basis of in vitro potency tests were used. Four other antigens, Histoplasmin, Dermatophytin-O, Dermatophytin, and fluid tetanus toxoid were also tested; positive reactions for these four antigens occurred in 48, 68, 25, and 43% of individuals, respectively. The mumps lots exhibited delayed hypersensitivity with positivity ranging from 63 to 67% at 20 CFU/ml and 77 to 84% at 80 CFU/ml in the acceptable lots. Side effects were primarily local and minor in nature. Mumps Skin Test Antigen is a useful measure of the integrity of the immune system, but lacks complete specificity because of local dermal factors.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalClinical Immunology and Immunopathology
Volume26
Issue number1
DOIs
StatePublished - Jan 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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