Delayed hypersensitivity to mumps antigen in humans

John Callaghan, Bruce H. Petersen, Wendell C. Smith, Warren W. Epinette, Robert C. Ransburg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sixty-one subjects, preselected for mumps sensitivity, were entered into a double-blind protocol to standardize Mumps Skin Test Antigen. Four lots of mumps antigen selected on the basis of in vitro potency tests were used. Four other antigens, Histoplasmin, Dermatophytin-O, Dermatophytin, and fluid tetanus toxoid were also tested; positive reactions for these four antigens occurred in 48, 68, 25, and 43% of individuals, respectively. The mumps lots exhibited delayed hypersensitivity with positivity ranging from 63 to 67% at 20 CFU/ml and 77 to 84% at 80 CFU/ml in the acceptable lots. Side effects were primarily local and minor in nature. Mumps Skin Test Antigen is a useful measure of the integrity of the immune system, but lacks complete specificity because of local dermal factors.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalClinical Immunology and Immunopathology
Volume26
Issue number1
DOIs
StatePublished - 1983

Fingerprint

Mumps
Delayed Hypersensitivity
Antigens
Skin Tests
Histoplasmin
Tetanus Toxoid
Immune System
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Delayed hypersensitivity to mumps antigen in humans. / Callaghan, John; Petersen, Bruce H.; Smith, Wendell C.; Epinette, Warren W.; Ransburg, Robert C.

In: Clinical Immunology and Immunopathology, Vol. 26, No. 1, 1983, p. 102-110.

Research output: Contribution to journalArticle

Callaghan, John ; Petersen, Bruce H. ; Smith, Wendell C. ; Epinette, Warren W. ; Ransburg, Robert C. / Delayed hypersensitivity to mumps antigen in humans. In: Clinical Immunology and Immunopathology. 1983 ; Vol. 26, No. 1. pp. 102-110.
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