Delayed loss of p75 neurotrophin receptor-immunoreactivity in the rat suprachiasmatic nucleus and intergeniculate leaflet after binocular enucleation

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Abstract

The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low- affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalNeuroscience Letters
Volume253
Issue number3
DOIs
StatePublished - Sep 3 1998

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Nerve Growth Factor Receptor
Suprachiasmatic Nucleus
Retinal Degeneration
Axons
Intercellular Signaling Peptides and Proteins
Up-Regulation

Keywords

  • Circadian rhythms
  • Hypothalamus
  • Nerve growth favtor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Delayed loss of p75 neurotrophin receptor-immunoreactivity in the rat suprachiasmatic nucleus and intergeniculate leaflet after binocular enucleation",
abstract = "The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low- affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.",
keywords = "Circadian rhythms, Hypothalamus, Nerve growth favtor",
author = "Margaret Moga",
year = "1998",
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pages = "187--190",
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AU - Moga, Margaret

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N2 - The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low- affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.

AB - The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low- affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.

KW - Circadian rhythms

KW - Hypothalamus

KW - Nerve growth favtor

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