Delayed loss of p75 neurotrophin receptor-immunoreactivity in the rat suprachiasmatic nucleus and intergeniculate leaflet after binocular enucleation

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The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low- affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Sep 3 1998



  • Circadian rhythms
  • Hypothalamus
  • Nerve growth favtor

ASJC Scopus subject areas

  • Neuroscience(all)

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