Delayed maze-learning in rats after prenatal exposure to clorazepate

Valerie Jackson, W. DeMyer, J. Hingtgen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Five pregnant Long-Evans rats were given 32 mg/kg of body weight of clorazepate dipotassium (Tranxene) intramuscularly on gestational days 8.5, 9.5, and 10.5. Five control mothers received sterile water. The control group of offspring (N = 19) and the experimental group (N = 20) were compared by means of a timetable for neurologic development and for maze learning ability. Although the experimental group was significantly slower in stomach-lifting and walking, the neurologic battery as a whole did not disclose any consistent difference. At 21 days of age, the experimental rats weighed significantly more than the control rats. The control rats learned the maze significantly faster than the experimental rats. On trials 10 to 14, the control group ran the maze in less than half of the time of the experimental group. The study emphasizes the need to include tests of cerebral function in addition to developmental reflexes to screen for subtle effects of teratogens, which the simpler developmental tests may miss.

Original languageEnglish
Pages (from-to)350-351
Number of pages2
JournalArchives of Neurology
Volume37
Issue number6
StatePublished - 1980

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Maze Learning
Clorazepate Dipotassium
Nervous System
Teratogens
Long Evans Rats
Control Groups
Aptitude
Walking
Reflex
Stomach
Body Weight
Rat
Water
Experimental Group

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Delayed maze-learning in rats after prenatal exposure to clorazepate. / Jackson, Valerie; DeMyer, W.; Hingtgen, J.

In: Archives of Neurology, Vol. 37, No. 6, 1980, p. 350-351.

Research output: Contribution to journalArticle

Jackson, V, DeMyer, W & Hingtgen, J 1980, 'Delayed maze-learning in rats after prenatal exposure to clorazepate', Archives of Neurology, vol. 37, no. 6, pp. 350-351.
Jackson, Valerie ; DeMyer, W. ; Hingtgen, J. / Delayed maze-learning in rats after prenatal exposure to clorazepate. In: Archives of Neurology. 1980 ; Vol. 37, No. 6. pp. 350-351.
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