Delayed orchiectomy after chemotherapy for metastatic nonseminomatous germ cell tumors

Ilan Leibovitch, J. Samuel Little, Richard S. Foster, Randall G. Rowland, Richard Bihrle, John P. Donohue

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Purpose: We reviewed current experience at our university with delayed orchiectomy after chemotherapy in patients with metastatic nonseminomatous germ cell tumors. Materials and Methods: We retrospectively analyzed the records of 160 patients with metastatic germ cell cancer who were given systemic chemotherapy, and subsequently underwent orchiectomy and retroperitoneal lymph node dissection. Results: Analysis of 160 testicular specimens revealed necrosis or scar in 70 (43.7%), pure teratoma in 50 (31.2%) and persistent germ cell cancer in 40 (25%). Corresponding incidences of histopathological findings in the post-chemotherapy retroperitoneal lymph node dissection specimens were significantly different, correlating with less than half of the cases (chi-square, p = 0.002). Conclusions: Our study confirms the need for delayed orchiectomy after systemic chemotherapy even when there seems to be a partial or complete clinical response at other sites.

Original languageEnglish (US)
Pages (from-to)952-954
Number of pages3
JournalJournal of Urology
Volume155
Issue number3
DOIs
StatePublished - Mar 1996

Keywords

  • drug therapy
  • orchiectomy
  • testicular neoplasms
  • testis

ASJC Scopus subject areas

  • Urology

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