Delayed type hypersensitivity to Staphylococcus aureus peptidoglycan in guinea pigs

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Skin hypersensitivity to Staphylococcus aureus peptidoglycan in guinea pigs was studied. For distinct skin reaction injection of 50 μg of the antigen was required. Nonsensitized guinea pigs and animals sensitized with emulsion of 1 mg or 100 μg of peptidoglycan with complete or incomplete Freund's adjuvant exhibited distinct immediate skin hypersensitivity. Nonsensitized animals did not show delayed type hypersensitivity (DTH). For development of DTH sensitization with 100 μg of the antigen with incomplete Freund's adjuvant was sufficient. The application of complete Freund's adjuvant resulted in intensification of DTH; however, also nonspecific sensitization to staphylococcal peptidoglycan with Mycobacterium butyricum cells, present in complete adjuvant, occurred.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume240
Issue number2
StatePublished - Dec 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Delayed type hypersensitivity to Staphylococcus aureus peptidoglycan in guinea pigs'. Together they form a unique fingerprint.

  • Cite this