Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Mi Ran Choi, Rizia Bardhan, Katie Stanton-Maxey, Sunil Badve, Harikrishna Nakshatri, Keith M. Stantz, Ning Cao, Naomi J. Halas, Susan E. Clare

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalCancer Nanotechnology
Volume3
Issue number1-6
DOIs
StatePublished - Dec 2012

Fingerprint

metastasis
breast
Nanoparticles
brain
Brain
delivery
cancer
Breast Neoplasms
blood-brain barrier
Neoplasm Metastasis
nanoparticles
Blood-Brain Barrier
monocytes
Disease control
central nervous system
macrophages
Macrophages
Central Nervous System Diseases
Neurology
Monocytes

Keywords

  • Blood-brain barrier
  • Brain metastasis
  • Breast cancer
  • Gold-silica nanoshell
  • Nanoparticle

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Pharmaceutical Science
  • Oncology
  • Biomedical Engineering

Cite this

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse. / Choi, Mi Ran; Bardhan, Rizia; Stanton-Maxey, Katie; Badve, Sunil; Nakshatri, Harikrishna; Stantz, Keith M.; Cao, Ning; Halas, Naomi J.; Clare, Susan E.

In: Cancer Nanotechnology, Vol. 3, No. 1-6, 12.2012, p. 47-54.

Research output: Contribution to journalArticle

Choi, Mi Ran ; Bardhan, Rizia ; Stanton-Maxey, Katie ; Badve, Sunil ; Nakshatri, Harikrishna ; Stantz, Keith M. ; Cao, Ning ; Halas, Naomi J. ; Clare, Susan E. / Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse. In: Cancer Nanotechnology. 2012 ; Vol. 3, No. 1-6. pp. 47-54.
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