Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Mi Ran Choi, Rizia Bardhan, Katie J. Stanton-Maxey, Sunil Badve, Harikrishna Nakshatri, Keith M. Stantz, Ning Cao, Naomi J. Halas, Susan E. Clare

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalCancer Nanotechnology
Volume3
Issue number1-6
DOIs
StatePublished - Dec 1 2012

Keywords

  • Blood-brain barrier
  • Brain metastasis
  • Breast cancer
  • Gold-silica nanoshell
  • Nanoparticle

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Pharmaceutical Science
  • Oncology
  • Biomedical Engineering

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