Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease

Hiroyuki Nakajima, Yutaka Sakakibara, Keiichi Tambara, Akira Marui, Momoko Yoshimoto, Goditha U. Premaratne, Xue Lin, Naoki Kanemitsu, Genichi Sakaguchi, Tadashi Ikeda, Kazunobu Nishimura, Tatsutoshi Nakahata, Masashi Komeda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results: MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM-and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV-and IMgroups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions: In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation.

Original languageEnglish (US)
Pages (from-to)1528-1535
Number of pages8
JournalCirculation Journal
Volume72
Issue number9
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Dilated Cardiomyopathy
Bone Marrow Transplantation
Heart Diseases
Myocardial Infarction
Green Fluorescent Proteins
Ventricular Remodeling
Intravenous Injections
Bone Marrow Cells
Doxorubicin
Injections

Keywords

  • Bone marrow cells
  • Cardiomyopathy
  • Myocardial infarction
  • Transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Nakajima, H., Sakakibara, Y., Tambara, K., Marui, A., Yoshimoto, M., Premaratne, G. U., ... Komeda, M. (2008). Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease. Circulation Journal, 72(9), 1528-1535. https://doi.org/10.1253/circj.CJ-06-0430

Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease. / Nakajima, Hiroyuki; Sakakibara, Yutaka; Tambara, Keiichi; Marui, Akira; Yoshimoto, Momoko; Premaratne, Goditha U.; Lin, Xue; Kanemitsu, Naoki; Sakaguchi, Genichi; Ikeda, Tadashi; Nishimura, Kazunobu; Nakahata, Tatsutoshi; Komeda, Masashi.

In: Circulation Journal, Vol. 72, No. 9, 2008, p. 1528-1535.

Research output: Contribution to journalArticle

Nakajima, H, Sakakibara, Y, Tambara, K, Marui, A, Yoshimoto, M, Premaratne, GU, Lin, X, Kanemitsu, N, Sakaguchi, G, Ikeda, T, Nishimura, K, Nakahata, T & Komeda, M 2008, 'Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease', Circulation Journal, vol. 72, no. 9, pp. 1528-1535. https://doi.org/10.1253/circj.CJ-06-0430
Nakajima, Hiroyuki ; Sakakibara, Yutaka ; Tambara, Keiichi ; Marui, Akira ; Yoshimoto, Momoko ; Premaratne, Goditha U. ; Lin, Xue ; Kanemitsu, Naoki ; Sakaguchi, Genichi ; Ikeda, Tadashi ; Nishimura, Kazunobu ; Nakahata, Tatsutoshi ; Komeda, Masashi. / Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease. In: Circulation Journal. 2008 ; Vol. 72, No. 9. pp. 1528-1535.
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abstract = "Background: Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results: MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM-and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV-and IMgroups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions: In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation.",
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author = "Hiroyuki Nakajima and Yutaka Sakakibara and Keiichi Tambara and Akira Marui and Momoko Yoshimoto and Premaratne, {Goditha U.} and Xue Lin and Naoki Kanemitsu and Genichi Sakaguchi and Tadashi Ikeda and Kazunobu Nishimura and Tatsutoshi Nakahata and Masashi Komeda",
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AU - Nakajima, Hiroyuki

AU - Sakakibara, Yutaka

AU - Tambara, Keiichi

AU - Marui, Akira

AU - Yoshimoto, Momoko

AU - Premaratne, Goditha U.

AU - Lin, Xue

AU - Kanemitsu, Naoki

AU - Sakaguchi, Genichi

AU - Ikeda, Tadashi

AU - Nishimura, Kazunobu

AU - Nakahata, Tatsutoshi

AU - Komeda, Masashi

PY - 2008

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N2 - Background: Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results: MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM-and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV-and IMgroups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions: In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation.

AB - Background: Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results: MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM-and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV-and IMgroups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions: In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation.

KW - Bone marrow cells

KW - Cardiomyopathy

KW - Myocardial infarction

KW - Transplantation

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