Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Madhavi Rangaswamy, Kevin A. Jones, Bernice Porjesz, David B. Chorlian, Ajayan Padmanabhapillai, Chella Kamarajan, Samuel Kuperman, John Rohrbaugh, Sean O'Connor, Lance O. Bauer, Marc A. Schuckit, Henri Begleiter

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Visual P300 is consistently lower in alcohol-dependent individuals, their offspring and subjects at risk. Delta and theta event-related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 ms post-stimulus window (corresponding to the zone of P300 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers. Methods: EEG was recorded during the performance of a visual oddball task. The S-transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitude for the target. Results: The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in the theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group. Conclusions: The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalInternational Journal of Psychophysiology
Volume63
Issue number1
DOIs
StatePublished - Jan 2007

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Alcoholics
Electroencephalography
Cholinergic Agents
Alcoholism
Power (Psychology)
Electrodes
Alcohols

Keywords

  • Adolescent
  • Alcoholism
  • Endophenotype
  • Highrisk
  • P300
  • Theta oscillation

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Rangaswamy, M., Jones, K. A., Porjesz, B., Chorlian, D. B., Padmanabhapillai, A., Kamarajan, C., ... Begleiter, H. (2007). Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. International Journal of Psychophysiology, 63(1), 3-15. https://doi.org/10.1016/j.ijpsycho.2006.10.003

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. / Rangaswamy, Madhavi; Jones, Kevin A.; Porjesz, Bernice; Chorlian, David B.; Padmanabhapillai, Ajayan; Kamarajan, Chella; Kuperman, Samuel; Rohrbaugh, John; O'Connor, Sean; Bauer, Lance O.; Schuckit, Marc A.; Begleiter, Henri.

In: International Journal of Psychophysiology, Vol. 63, No. 1, 01.2007, p. 3-15.

Research output: Contribution to journalArticle

Rangaswamy, M, Jones, KA, Porjesz, B, Chorlian, DB, Padmanabhapillai, A, Kamarajan, C, Kuperman, S, Rohrbaugh, J, O'Connor, S, Bauer, LO, Schuckit, MA & Begleiter, H 2007, 'Delta and theta oscillations as risk markers in adolescent offspring of alcoholics', International Journal of Psychophysiology, vol. 63, no. 1, pp. 3-15. https://doi.org/10.1016/j.ijpsycho.2006.10.003
Rangaswamy, Madhavi ; Jones, Kevin A. ; Porjesz, Bernice ; Chorlian, David B. ; Padmanabhapillai, Ajayan ; Kamarajan, Chella ; Kuperman, Samuel ; Rohrbaugh, John ; O'Connor, Sean ; Bauer, Lance O. ; Schuckit, Marc A. ; Begleiter, Henri. / Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. In: International Journal of Psychophysiology. 2007 ; Vol. 63, No. 1. pp. 3-15.
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abstract = "Background: Visual P300 is consistently lower in alcohol-dependent individuals, their offspring and subjects at risk. Delta and theta event-related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 ms post-stimulus window (corresponding to the zone of P300 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers. Methods: EEG was recorded during the performance of a visual oddball task. The S-transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitude for the target. Results: The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in the theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group. Conclusions: The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.",
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AU - Kamarajan, Chella

AU - Kuperman, Samuel

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