Dementia incidence declined in African-Americans but not in Yoruba

Sujuan Gao, Adesola Ogunniyi, Kathleen S. Hall, Olusegun Baiyewu, Frederick W. Unverzagt, Kathleen A. Lane, Jill R. Murrell, Oye Gureje, Ann M. Hake, Hugh C. Hendrie

Research output: Contribution to journalArticle

28 Scopus citations


Background: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and2001. Methods: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Conclusions: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 1 2016


  • African-Americans
  • Alzheimer's disease
  • Dementia
  • Incidence
  • Nigerians

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

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