Dementia incidence declined in African-Americans but not in Yoruba

Sujuan Gao, Adesola Ogunniyi, Kathleen Hall, Olusegun Baiyewu, Frederick Unverzagt, Kathleen A. Lane, Jill R. Murrell, Oye Gureje, Ann Hake, Hugh Hendrie

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and2001. Methods: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Conclusions: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.

Original languageEnglish
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2015

Fingerprint

African Americans
Dementia
Incidence
Alzheimer Disease
Confidence Intervals
Nigeria
Age Groups
Population

Keywords

  • African-Americans
  • Alzheimer's disease
  • Dementia
  • Incidence
  • Nigerians

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Dementia incidence declined in African-Americans but not in Yoruba. / Gao, Sujuan; Ogunniyi, Adesola; Hall, Kathleen; Baiyewu, Olusegun; Unverzagt, Frederick; Lane, Kathleen A.; Murrell, Jill R.; Gureje, Oye; Hake, Ann; Hendrie, Hugh.

In: Alzheimer's and Dementia, 2015.

Research output: Contribution to journalArticle

@article{72d3f503cfd149e8b67ea1d2e1da0fd0,
title = "Dementia incidence declined in African-Americans but not in Yoruba",
abstract = "Background: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and2001. Methods: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6{\%} (95{\%} confidence interval [CI], 3.2{\%}-4.1{\%}) in the 1992 cohort and 1.4{\%} (95{\%} CI, 1.2{\%}-1.7{\%}) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Conclusions: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.",
keywords = "African-Americans, Alzheimer's disease, Dementia, Incidence, Nigerians",
author = "Sujuan Gao and Adesola Ogunniyi and Kathleen Hall and Olusegun Baiyewu and Frederick Unverzagt and Lane, {Kathleen A.} and Murrell, {Jill R.} and Oye Gureje and Ann Hake and Hugh Hendrie",
year = "2015",
doi = "10.1016/j.jalz.2015.06.1894",
language = "English",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Dementia incidence declined in African-Americans but not in Yoruba

AU - Gao, Sujuan

AU - Ogunniyi, Adesola

AU - Hall, Kathleen

AU - Baiyewu, Olusegun

AU - Unverzagt, Frederick

AU - Lane, Kathleen A.

AU - Murrell, Jill R.

AU - Gureje, Oye

AU - Hake, Ann

AU - Hendrie, Hugh

PY - 2015

Y1 - 2015

N2 - Background: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and2001. Methods: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Conclusions: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.

AB - Background: To compare dementia incidence of African-American and Yoruba cohorts aged ≥70 years enrolled in 1992 and2001. Methods: African-Americans residing in Indianapolis and Yoruba in Ibadan, Nigeria without dementia were enrolled in 1992 and 2001 and evaluated every 2-3 years until 2009. The cohorts consist of 1440 African-Americans, 1774 Yoruba in 1992 and 1835 African-Americans and 1895 Yoruba in the 2001 cohorts aged ≥70 years. Results: In African-Americans, dementia and Alzheimer's disease (AD) incidence rates were significantly lower in 2001 than 1992 for all age groups except the oldest group. The overall standardized annual dementia incidence rates were 3.6% (95% confidence interval [CI], 3.2%-4.1%) in the 1992 cohort and 1.4% (95% CI, 1.2%-1.7%) in the 2001 cohort. There was no significant difference in dementia or AD incidence between the Yoruba cohorts. Conclusions: Future research is needed to explore the reasons for the differential changes in incidence rates in these two populations.

KW - African-Americans

KW - Alzheimer's disease

KW - Dementia

KW - Incidence

KW - Nigerians

UR - http://www.scopus.com/inward/record.url?scp=84939533503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939533503&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2015.06.1894

DO - 10.1016/j.jalz.2015.06.1894

M3 - Article

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

ER -