Dendritic cells: Controllers of the immune system and a new promise for immunotherapy

Jacques Banchereau, Sophie Paczesny, Patrick Blanco, Lynda Bennett, Virginia Pascual, Joseph Fay, A. Karolina Palucka

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β upon viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume987
StatePublished - 2003
Externally publishedYes

Fingerprint

Immune system
Immunotherapy
Dendritic Cells
Immune System
Controllers
Lymphocytes
Langerhans Cells
Launching
Interleukin-12
Set theory
Interleukin-10
Cell Differentiation
Immunity
B-Lymphocytes
Cells
Modulation

Keywords

  • Dendritic cells
  • Immunotherapy
  • Interstitial DCs
  • Langerhans cells
  • T cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Banchereau, J., Paczesny, S., Blanco, P., Bennett, L., Pascual, V., Fay, J., & Palucka, A. K. (2003). Dendritic cells: Controllers of the immune system and a new promise for immunotherapy. Annals of the New York Academy of Sciences, 987, 180-187.

Dendritic cells : Controllers of the immune system and a new promise for immunotherapy. / Banchereau, Jacques; Paczesny, Sophie; Blanco, Patrick; Bennett, Lynda; Pascual, Virginia; Fay, Joseph; Palucka, A. Karolina.

In: Annals of the New York Academy of Sciences, Vol. 987, 2003, p. 180-187.

Research output: Contribution to journalArticle

Banchereau, J, Paczesny, S, Blanco, P, Bennett, L, Pascual, V, Fay, J & Palucka, AK 2003, 'Dendritic cells: Controllers of the immune system and a new promise for immunotherapy', Annals of the New York Academy of Sciences, vol. 987, pp. 180-187.
Banchereau, Jacques ; Paczesny, Sophie ; Blanco, Patrick ; Bennett, Lynda ; Pascual, Virginia ; Fay, Joseph ; Palucka, A. Karolina. / Dendritic cells : Controllers of the immune system and a new promise for immunotherapy. In: Annals of the New York Academy of Sciences. 2003 ; Vol. 987. pp. 180-187.
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