Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

W. J. McBride, E. Chernet, W. Dyr, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The densities of dopamine D2 recognition sites labelled with [3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P (N = 7) and NP (N = 7) rats using quantitative autoradiography. The binding of [3H]sulpiride was 20-25% lower (P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D2 recognition sites in the caudate-putamen between the P and NP rats was due to lower Bmax values for the P line. The results indicate that the number of dopamine D2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalAlcohol
Volume10
Issue number5
DOIs
StatePublished - 1993

Fingerprint

Dopamine D2 Receptors
Rats
alcohol
Alcohols
Sulpiride
Putamen
Ventral Tegmental Area
Nucleus Accumbens
Values
Caudate Nucleus
Neurology
Substantia Nigra
Autoradiography
Dopamine
Central Nervous System
Membranes

Keywords

  • Alcohol preference
  • Alcohol-preferring rats
  • Dopamine receptors
  • Dopamine-2 receptors
  • Nucleus accumbens
  • Sulpiride
  • Ventral tegmental area

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats. / McBride, W. J.; Chernet, E.; Dyr, W.; Lumeng, L.; Li, T. K.

In: Alcohol, Vol. 10, No. 5, 1993, p. 387-390.

Research output: Contribution to journalArticle

McBride, W. J. ; Chernet, E. ; Dyr, W. ; Lumeng, L. ; Li, T. K. / Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats. In: Alcohol. 1993 ; Vol. 10, No. 5. pp. 387-390.
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