Dental caries

Nigel B. Pitts, Domenick T. Zero, Phil D. Marsh, Kim Ekstrand, Jane A. Weintraub, Francisco Ramos-Gomez, Junji Tagami, Svante Twetman, Georgios Tsakos, Amid Ismail

Research output: Contribution to journalArticle

211 Scopus citations

Abstract

Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. Caries can occur throughout life, both in primary and permanent dentitions, and can damage the tooth crown and, in later life, exposed root surfaces. The balance between pathological and protective factors influences the initiation and progression of caries. This interplay between factors underpins the classification of individuals and groups into caries risk categories, allowing an increasingly tailored approach to care. Dental caries is an unevenly distributed, preventable disease with considerable economic and quality-of-life burdens. The daily use of fluoride toothpaste is seen as the main reason for the overall decline of caries worldwide over recent decades. This Primer aims to provide a global overview of caries, acknowledging the historical era dominated by restoration of tooth decay by surgical means, but focuses on current, progressive and more holistic long-term, patient-centred, tooth-preserving preventive care.

Original languageEnglish (US)
Article number17030
JournalNature Reviews Disease Primers
Volume3
DOIs
StatePublished - May 25 2017

ASJC Scopus subject areas

  • Medicine(all)

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