Dental fluorosis: Variability among different inbred mouse strains

E. T. Everett, M. A K McHenry, N. Reynolds, H. Eggertsson, J. Sullivan, C. Kantmann, Esperanza Martinez Mier, J. M. Warrick, G. K. Stookey

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Concurrent with the decline in dental caries has been an increase in the prevalence of dental fluorosis, a side-effect of exposure to greater than optimal levels of fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental fluorosis are not known. We hypothesize that genetic determinants influence an individual's susceptibility or resistance to develop dental fluorosis. We tested this hypothesis using a mouse model system (continuous eruption of the incisors) where genotype, age, gender, food, housing, and drinking water fluoride level can be rigorously controlled. Examination of 12 inbred strains of mice showed differences in dental fluorosis susceptibility/resistance. The A/J mouse strain is highly susceptible, with a rapid onset and severe development of dental fluorosis compared with that in the other strains tested, whereas the 129P3/J mouse strain is least affected, with minimal dental fluorosis. These observations support the contribution of a genetic component in the pathogenesis of dental fluorosis.

Original languageEnglish (US)
Pages (from-to)794-798
Number of pages5
JournalJournal of Dental Research
Volume81
Issue number11
StatePublished - Nov 1 2002

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Dental Fluorosis
Inbred Strains Mice
Fluorides
Amelogenesis
Dental Caries
Incisor
Drinking Water
Genotype
Food

Keywords

  • Dental fluorosis
  • Inbred mouse strains
  • Quantitative light-induced fluorescence

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Everett, E. T., McHenry, M. A. K., Reynolds, N., Eggertsson, H., Sullivan, J., Kantmann, C., ... Stookey, G. K. (2002). Dental fluorosis: Variability among different inbred mouse strains. Journal of Dental Research, 81(11), 794-798.

Dental fluorosis : Variability among different inbred mouse strains. / Everett, E. T.; McHenry, M. A K; Reynolds, N.; Eggertsson, H.; Sullivan, J.; Kantmann, C.; Martinez Mier, Esperanza; Warrick, J. M.; Stookey, G. K.

In: Journal of Dental Research, Vol. 81, No. 11, 01.11.2002, p. 794-798.

Research output: Contribution to journalArticle

Everett, ET, McHenry, MAK, Reynolds, N, Eggertsson, H, Sullivan, J, Kantmann, C, Martinez Mier, E, Warrick, JM & Stookey, GK 2002, 'Dental fluorosis: Variability among different inbred mouse strains', Journal of Dental Research, vol. 81, no. 11, pp. 794-798.
Everett ET, McHenry MAK, Reynolds N, Eggertsson H, Sullivan J, Kantmann C et al. Dental fluorosis: Variability among different inbred mouse strains. Journal of Dental Research. 2002 Nov 1;81(11):794-798.
Everett, E. T. ; McHenry, M. A K ; Reynolds, N. ; Eggertsson, H. ; Sullivan, J. ; Kantmann, C. ; Martinez Mier, Esperanza ; Warrick, J. M. ; Stookey, G. K. / Dental fluorosis : Variability among different inbred mouse strains. In: Journal of Dental Research. 2002 ; Vol. 81, No. 11. pp. 794-798.
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