Improved methods of bone regeneration are needed to greatly improve the medical treatment options to vast numbers of patients suffering from different types of bone injury. Bone can be injured in many ways: as a result of trauma or aging, and from diseases such as cancer, osteoporosis, and periodontal disease. Drug side effects, as seen when using bisphosphonate for treatment of osteoporosis and metastatic bone cancer, can also destroy bone [1, 2]. Specific indications for bone repair in dental and craniofacial reconstruction include bone augmentation prior to prosthetic reconstruction, fracture repair, and repair of bone defects secondary to trauma, tumor resection, and congenital deformities. In roughly half of all individuals in the United States, periodontal disease alone is projected to result in the loss of six teeth per individual by age 65 years [3, 4]. Clearly, bone loss remains a major health care concern.
|Original language||English (US)|
|Title of host publication||Fundamentals of Tissue Engineering and Regenerative Medicine|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||23|
|State||Published - Dec 1 2009|
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