Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes

Stephanie C. Colvin, Bernhard Maier, David L. Morris, Sarah A. Tersey, Raghavendra G. Mirmira

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: Deoxyhypusine synthase promotes mRNA translation by catalyzing the hypusine modification of eIF5A. Results: Inhibition of deoxyhypusine synthase reduced accumulation and proliferation of Th1 cells in type 1 diabetic mice and in vitro by reducing CD25 expression in T cells. Conclusion: Deoxyhypusine synthase promotes Th1 cell proliferation and differentiation. Significance: Inhibition of deoxyhypusine synthase may provide a novel strategy for reducing diabetogenic Th1 cells in type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)36226-36235
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number51
DOIs
StatePublished - Dec 20 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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