Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes

Stephanie C. Colvin, Bernhard Maier, David L. Morris, Sarah A. Tersey, Raghu Mirmira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Deoxyhypusine synthase promotes mRNA translation by catalyzing the hypusine modification of eIF5A. Results: Inhibition of deoxyhypusine synthase reduced accumulation and proliferation of Th1 cells in type 1 diabetic mice and in vitro by reducing CD25 expression in T cells. Conclusion: Deoxyhypusine synthase promotes Th1 cell proliferation and differentiation. Significance: Inhibition of deoxyhypusine synthase may provide a novel strategy for reducing diabetogenic Th1 cells in type 1 diabetes.

Original languageEnglish
Pages (from-to)36226-36235
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number51
DOIs
StatePublished - Dec 20 2013

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Th1 Cells
Medical problems
Type 1 Diabetes Mellitus
T-cells
Cell proliferation
Protein Biosynthesis
Cell Differentiation
Cell Proliferation
T-Lymphocytes
Messenger RNA
deoxyhypusine synthase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. / Colvin, Stephanie C.; Maier, Bernhard; Morris, David L.; Tersey, Sarah A.; Mirmira, Raghu.

In: Journal of Biological Chemistry, Vol. 288, No. 51, 20.12.2013, p. 36226-36235.

Research output: Contribution to journalArticle

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