Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder: an analysis of 36 cases

David Grignon, A. El-Naggar, J. Y. Ro, D. E. Johnson, A. G. Ayala

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Deoxyribonucleic acid flow cytometry was applied retrospectively to 36 primary pure adenocarcinomas of the bladder, stages A through D. Six tumors were enteric, 3 mucinous, 11 signet ring, 3 papillary, 5 unspecified and 8 mixed. Eight tumors were urachal in origin and 28 were nonurachal. The deoxyribonucleic acid pattern was diploid in 12 cases, aneuploid in 19, tetraploid in 3 and uncertain in 2. Nineteen patients died of disease after a mean of 27.4 months, 7 were well at a mean of 73.9 months, 8 had died of an unrelated cause and 1 was alive with metastatic disease. Ploidy pattern did not correlate with tumor stage, histological pattern or type of outcome: 6 of 12 patients with diploid and 12 of 22 with nondiploid tumors died of disease. However, if the tumor was urachal 1 of 4 patients with a diploid pattern died of disease, while 3 of 4 with an aneuploid pattern either died or were alive with disease. Our data suggest that deoxyribonucleic acid ploidy pattern apparently is not a significant predictor of outcome for primary adenocarcinoma of the bladder except possibly when the origin is urachal.

Original languageEnglish (US)
Pages (from-to)1206-1210
Number of pages5
JournalJournal of Urology
Volume142
Issue number5
StatePublished - 1989
Externally publishedYes

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Flow Cytometry
Urinary Bladder
Adenocarcinoma
Diploidy
DNA
Ploidies
Aneuploidy
Neoplasms
Tetraploidy

ASJC Scopus subject areas

  • Urology

Cite this

Grignon, D., El-Naggar, A., Ro, J. Y., Johnson, D. E., & Ayala, A. G. (1989). Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder: an analysis of 36 cases. Journal of Urology, 142(5), 1206-1210.

Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder : an analysis of 36 cases. / Grignon, David; El-Naggar, A.; Ro, J. Y.; Johnson, D. E.; Ayala, A. G.

In: Journal of Urology, Vol. 142, No. 5, 1989, p. 1206-1210.

Research output: Contribution to journalArticle

Grignon, D, El-Naggar, A, Ro, JY, Johnson, DE & Ayala, AG 1989, 'Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder: an analysis of 36 cases', Journal of Urology, vol. 142, no. 5, pp. 1206-1210.
Grignon, David ; El-Naggar, A. ; Ro, J. Y. ; Johnson, D. E. ; Ayala, A. G. / Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder : an analysis of 36 cases. In: Journal of Urology. 1989 ; Vol. 142, No. 5. pp. 1206-1210.
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