Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Repeated administration of deprenyl (10 or 20 mg/kg/day for 4 days, s.c.) increased the levels of Met-enkephalin (ME) and preproenkephalin mRNA (PE-mRNA) in the striatum whereas lower doses (0.25, 0.5 or 5 mg/kg/day for 4 days) did not affect the levels. A high dose of clorgyline also increased ME levels. It appears that a high degree of inhibition of monoamine oxidase (MAO) activity is associated with an increase in enkephalin biosynthesis.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
StatePublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sivam, S. P. (1990). Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..