Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Repeated administration of deprenyl (10 or 20 mg/kg/day for 4 days, s.c.) increased the levels of Met-enkephalin (ME) and preproenkephalin mRNA (PE-mRNA) in the striatum whereas lower doses (0.25, 0.5 or 5 mg/kg/day for 4 days) did not affect the levels. A high dose of clorgyline also increased ME levels. It appears that a high degree of inhibition of monoamine oxidase (MAO) activity is associated with an increase in enkephalin biosynthesis.

Original languageEnglish
Title of host publicationNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages357
Number of pages1
ISBN (Print)044481213X
StatePublished - 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

Fingerprint

Selegiline
Corpus Striatum
Methionine Enkephalin
Enkephalins
Clorgyline
Messenger RNA
Monoamine Oxidase
preproenkephalin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sivam, S. (1990). Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, ... T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 357). Elsevier Science Publishers B.V..

Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. / Sivam, Subbiah.

New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 357.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sivam, S 1990, Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V., pp. 357, The International Narcotics Research Conference, 7/8/89.
Sivam S. Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 357
Sivam, Subbiah. / Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 357
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