Depression and poor glycemic control: A meta-analytic review of the literature

Patrick J. Lustman, Ryan J. Anderson, Kenneth E. Freedland, Mary De Groot, Robert M. Carney, Ray E. Clouse

Research output: Contribution to journalArticle

1211 Citations (Scopus)

Abstract

OBJECTIVE - Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS - Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were used to convert the findings to a common metric, calculate effect sizes (ESs), and statistically analyze the collective data. RESULTS - A total of 24 studies satisfied the inclusion and exclusion criteria for the metaanalysis. Depression was significantly associated with hyperglycemia (Z = 5.4. P < 0.0001). The standardized ES was in the small-to-moderate range (0.17) and was consistent, as the 95% CI was narrow (0.13 - 0.21). The ES was similar in studies of either type 1 or type 2 diabetes (ES 0.19 vs. 0.16) and larger when standardized interviews and diagnostic criteria rather than self- report questionnaires were used to assess depression (ES 0.28 vs. 0.15). CONCLUSIONS - Depression is associated with hyperglycemia in patients with type 1 or type 2 diabetes. Additional studies are needed to establish the directional nature of this relationship and to determine the effects of depression treatment on glycemic control and the long-term course of diabetes.

Original languageEnglish (US)
Pages (from-to)934-942
Number of pages9
JournalDiabetes care
Volume23
Issue number7
DOIs
StatePublished - Jan 1 2000

Fingerprint

Hyperglycemia
Type 2 Diabetes Mellitus
Self Report
Research Design
Databases
Interviews
Therapeutics
Surveys and Questionnaires

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Lustman, P. J., Anderson, R. J., Freedland, K. E., De Groot, M., Carney, R. M., & Clouse, R. E. (2000). Depression and poor glycemic control: A meta-analytic review of the literature. Diabetes care, 23(7), 934-942. https://doi.org/10.2337/diacare.23.7.934

Depression and poor glycemic control : A meta-analytic review of the literature. / Lustman, Patrick J.; Anderson, Ryan J.; Freedland, Kenneth E.; De Groot, Mary; Carney, Robert M.; Clouse, Ray E.

In: Diabetes care, Vol. 23, No. 7, 01.01.2000, p. 934-942.

Research output: Contribution to journalArticle

Lustman, PJ, Anderson, RJ, Freedland, KE, De Groot, M, Carney, RM & Clouse, RE 2000, 'Depression and poor glycemic control: A meta-analytic review of the literature', Diabetes care, vol. 23, no. 7, pp. 934-942. https://doi.org/10.2337/diacare.23.7.934
Lustman, Patrick J. ; Anderson, Ryan J. ; Freedland, Kenneth E. ; De Groot, Mary ; Carney, Robert M. ; Clouse, Ray E. / Depression and poor glycemic control : A meta-analytic review of the literature. In: Diabetes care. 2000 ; Vol. 23, No. 7. pp. 934-942.
@article{e5ad3a95f7fd44a889c864918a7e16ea,
title = "Depression and poor glycemic control: A meta-analytic review of the literature",
abstract = "OBJECTIVE - Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS - Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were used to convert the findings to a common metric, calculate effect sizes (ESs), and statistically analyze the collective data. RESULTS - A total of 24 studies satisfied the inclusion and exclusion criteria for the metaanalysis. Depression was significantly associated with hyperglycemia (Z = 5.4. P < 0.0001). The standardized ES was in the small-to-moderate range (0.17) and was consistent, as the 95{\%} CI was narrow (0.13 - 0.21). The ES was similar in studies of either type 1 or type 2 diabetes (ES 0.19 vs. 0.16) and larger when standardized interviews and diagnostic criteria rather than self- report questionnaires were used to assess depression (ES 0.28 vs. 0.15). CONCLUSIONS - Depression is associated with hyperglycemia in patients with type 1 or type 2 diabetes. Additional studies are needed to establish the directional nature of this relationship and to determine the effects of depression treatment on glycemic control and the long-term course of diabetes.",
author = "Lustman, {Patrick J.} and Anderson, {Ryan J.} and Freedland, {Kenneth E.} and {De Groot}, Mary and Carney, {Robert M.} and Clouse, {Ray E.}",
year = "2000",
month = "1",
day = "1",
doi = "10.2337/diacare.23.7.934",
language = "English (US)",
volume = "23",
pages = "934--942",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "7",

}

TY - JOUR

T1 - Depression and poor glycemic control

T2 - A meta-analytic review of the literature

AU - Lustman, Patrick J.

AU - Anderson, Ryan J.

AU - Freedland, Kenneth E.

AU - De Groot, Mary

AU - Carney, Robert M.

AU - Clouse, Ray E.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - OBJECTIVE - Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS - Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were used to convert the findings to a common metric, calculate effect sizes (ESs), and statistically analyze the collective data. RESULTS - A total of 24 studies satisfied the inclusion and exclusion criteria for the metaanalysis. Depression was significantly associated with hyperglycemia (Z = 5.4. P < 0.0001). The standardized ES was in the small-to-moderate range (0.17) and was consistent, as the 95% CI was narrow (0.13 - 0.21). The ES was similar in studies of either type 1 or type 2 diabetes (ES 0.19 vs. 0.16) and larger when standardized interviews and diagnostic criteria rather than self- report questionnaires were used to assess depression (ES 0.28 vs. 0.15). CONCLUSIONS - Depression is associated with hyperglycemia in patients with type 1 or type 2 diabetes. Additional studies are needed to establish the directional nature of this relationship and to determine the effects of depression treatment on glycemic control and the long-term course of diabetes.

AB - OBJECTIVE - Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control. RESEARCH DESIGN AND METHODS - Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were used to convert the findings to a common metric, calculate effect sizes (ESs), and statistically analyze the collective data. RESULTS - A total of 24 studies satisfied the inclusion and exclusion criteria for the metaanalysis. Depression was significantly associated with hyperglycemia (Z = 5.4. P < 0.0001). The standardized ES was in the small-to-moderate range (0.17) and was consistent, as the 95% CI was narrow (0.13 - 0.21). The ES was similar in studies of either type 1 or type 2 diabetes (ES 0.19 vs. 0.16) and larger when standardized interviews and diagnostic criteria rather than self- report questionnaires were used to assess depression (ES 0.28 vs. 0.15). CONCLUSIONS - Depression is associated with hyperglycemia in patients with type 1 or type 2 diabetes. Additional studies are needed to establish the directional nature of this relationship and to determine the effects of depression treatment on glycemic control and the long-term course of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0033927080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033927080&partnerID=8YFLogxK

U2 - 10.2337/diacare.23.7.934

DO - 10.2337/diacare.23.7.934

M3 - Article

C2 - 10895843

AN - SCOPUS:0033927080

VL - 23

SP - 934

EP - 942

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 7

ER -