Depressive symptoms and inflammatory biomarkers in patients with heart failure

Rebecca L. Dekker, Debra K. Moser, Elizabeth G. Tovar, Misook L. Chung, Seongkum Heo, Jia Rong Wu, Sandra B. Dunbar, Susan Pressler, Terry A. Lennie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aim: To determine which inflammatory biomarkers are independently associated with depressive symptoms in heart failure.

Methods and results: We analyzed data from 428 outpatients enrolled in a heart failure registry (32% female, 61 } 12 years, 48% New York Heart Association Class III/IV). Depressive symptoms were measured with the Beck Depression Inventory-II. Serum C-reactive protein (CRP), cytokines (interleukin 1 receptor antagonist, 2, 4, 6, 8, 10), tumor necrosis alpha, and soluble receptors sTNFR1 and sTNFR2 were measured with enzyme immunoassay. Multiple regressions were used to determine which biomarkers were associated with depressive symptoms controlling for demographics, heart failure severity, and clinical variables. Twenty-seven percent (n = 119) had depressive symptoms. CRP was related to depressive symptoms after controlling for age and gender, but no inflammatory biomarkers were associated with depressive symptoms after controlling for all variables in the model.

Background: Inflammation may be a link between depressive symptoms and outcomes in patients with heart failure. It is not clear whether inflammatory markers are independently related to depressive symptoms in this population.

Conclusions: There was no relationship between inflammatory biomarkers and depressive symptoms. Our findings, in combination with prior researchers', suggest there is not a robust relationship between depressive symptoms and individual biomarkers of inflammation in heart failure.

Original languageEnglish (US)
Pages (from-to)444-450
Number of pages7
JournalEuropean Journal of Cardiovascular Nursing
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Heart Failure
Biomarkers
Depression
C-Reactive Protein
Inflammation
Interleukin-1 Receptors
Immunoenzyme Techniques
Registries
Blood Proteins
Necrosis
Outpatients
Research Personnel
Demography
Cytokines
Equipment and Supplies
Population

Keywords

  • cardiovascular
  • cytokines
  • depression
  • heart failure
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing
  • Medical–Surgical
  • Medicine(all)

Cite this

Dekker, R. L., Moser, D. K., Tovar, E. G., Chung, M. L., Heo, S., Wu, J. R., ... Lennie, T. A. (2014). Depressive symptoms and inflammatory biomarkers in patients with heart failure. European Journal of Cardiovascular Nursing, 13(5), 444-450. https://doi.org/10.1177/1474515113507508

Depressive symptoms and inflammatory biomarkers in patients with heart failure. / Dekker, Rebecca L.; Moser, Debra K.; Tovar, Elizabeth G.; Chung, Misook L.; Heo, Seongkum; Wu, Jia Rong; Dunbar, Sandra B.; Pressler, Susan; Lennie, Terry A.

In: European Journal of Cardiovascular Nursing, Vol. 13, No. 5, 01.10.2014, p. 444-450.

Research output: Contribution to journalArticle

Dekker, RL, Moser, DK, Tovar, EG, Chung, ML, Heo, S, Wu, JR, Dunbar, SB, Pressler, S & Lennie, TA 2014, 'Depressive symptoms and inflammatory biomarkers in patients with heart failure', European Journal of Cardiovascular Nursing, vol. 13, no. 5, pp. 444-450. https://doi.org/10.1177/1474515113507508
Dekker, Rebecca L. ; Moser, Debra K. ; Tovar, Elizabeth G. ; Chung, Misook L. ; Heo, Seongkum ; Wu, Jia Rong ; Dunbar, Sandra B. ; Pressler, Susan ; Lennie, Terry A. / Depressive symptoms and inflammatory biomarkers in patients with heart failure. In: European Journal of Cardiovascular Nursing. 2014 ; Vol. 13, No. 5. pp. 444-450.
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