Depressive symptoms are associated with fasting insulin resistance in obese youth

Tamara Hannon, Z. Li, Wanzhu Tu, J. N. Huber, Aaron Carroll, A. M. Lagges, Sandeep Gupta

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: In adults, depressive symptoms are positively associated with insulin resistance. Objective: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. Methods: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance. Results: Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049). Conclusions: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

Original languageEnglish
Pages (from-to)e103-e107
JournalPediatric obesity
Volume9
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Insulin Resistance
Fasting
Depression
Equipment and Supplies
Insulin
Linear Models
Body Mass Index
Obesity

Keywords

  • Adolescent
  • Depression
  • Insulin sensitivity
  • Overweight

ASJC Scopus subject areas

  • Health Policy
  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics

Cite this

Depressive symptoms are associated with fasting insulin resistance in obese youth. / Hannon, Tamara; Li, Z.; Tu, Wanzhu; Huber, J. N.; Carroll, Aaron; Lagges, A. M.; Gupta, Sandeep.

In: Pediatric obesity, Vol. 9, No. 5, 2014, p. e103-e107.

Research output: Contribution to journalArticle

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