Depressive symptoms are associated with fasting insulin resistance in obese youth

T. S. Hannon, Z. Li, W. Tu, J. N. Huber, A. E. Carroll, A. M. Lagges, S. Gupta

Research output: Contribution to journalArticle

Abstract

BACKGROUND: In adults, depressive symptoms are positively associated with insulin resistance.

OBJECTIVE: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth.

METHODS: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance.

RESULTS: Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049).

CONCLUSIONS: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

Original languageEnglish (US)
Pages (from-to)e103-e107
JournalPediatric obesity
Volume9
Issue number5
DOIs
StatePublished - Oct 1 2014

Fingerprint

Insulin Resistance
Fasting
Depression
Equipment and Supplies
Insulin
Linear Models
Body Mass Index
Obesity

Keywords

  • Adolescent
  • depression
  • insulin sensitivity
  • overweight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Depressive symptoms are associated with fasting insulin resistance in obese youth. / Hannon, T. S.; Li, Z.; Tu, W.; Huber, J. N.; Carroll, A. E.; Lagges, A. M.; Gupta, S.

In: Pediatric obesity, Vol. 9, No. 5, 01.10.2014, p. e103-e107.

Research output: Contribution to journalArticle

@article{ed126b4280d34401b9c5d22c6f7966f5,
title = "Depressive symptoms are associated with fasting insulin resistance in obese youth",
abstract = "BACKGROUND: In adults, depressive symptoms are positively associated with insulin resistance.OBJECTIVE: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth.METHODS: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance.RESULTS: Fasting insulin and HOMA-IR values were 40{\%} higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049).CONCLUSIONS: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.",
keywords = "Adolescent, depression, insulin sensitivity, overweight",
author = "Hannon, {T. S.} and Z. Li and W. Tu and Huber, {J. N.} and Carroll, {A. E.} and Lagges, {A. M.} and S. Gupta",
year = "2014",
month = "10",
day = "1",
doi = "10.1111/ijpo.237",
language = "English (US)",
volume = "9",
pages = "e103--e107",
journal = "Pediatric obesity",
issn = "2047-6310",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "5",

}

TY - JOUR

T1 - Depressive symptoms are associated with fasting insulin resistance in obese youth

AU - Hannon, T. S.

AU - Li, Z.

AU - Tu, W.

AU - Huber, J. N.

AU - Carroll, A. E.

AU - Lagges, A. M.

AU - Gupta, S.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BACKGROUND: In adults, depressive symptoms are positively associated with insulin resistance.OBJECTIVE: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth.METHODS: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance.RESULTS: Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049).CONCLUSIONS: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

AB - BACKGROUND: In adults, depressive symptoms are positively associated with insulin resistance.OBJECTIVE: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth.METHODS: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (<65 vs. ≥65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance.RESULTS: Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049).CONCLUSIONS: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

KW - Adolescent

KW - depression

KW - insulin sensitivity

KW - overweight

UR - http://www.scopus.com/inward/record.url?scp=85006309032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006309032&partnerID=8YFLogxK

U2 - 10.1111/ijpo.237

DO - 10.1111/ijpo.237

M3 - Article

C2 - 24861610

VL - 9

SP - e103-e107

JO - Pediatric obesity

JF - Pediatric obesity

SN - 2047-6310

IS - 5

ER -