Design and manufacture of bone replacement scaffolds

Scott J. Hollister, Tien Min Gabriel Chu, John W. Halloran, Stephen E. Feinberg

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Although both bone grafting and synthetic material reconstruction have been successful in many applications, their shortcomings have motivated a third approach to bone reconstruction, tissue engineering. Tissue engineering combines biologic regenerative factors, like stromal cells or growth factors, with biodegradable material scaffolds, like calcium phosphate ceramics and polylactic and polyglycolic acid polymers. The scaffold provides initial function but slowly degrades as healing bone tissue gradually takes over more function. In theory, tissue engineering provides the best of bone grafting and synthetic material reconstruction. Like synthetic reconstruction, tissue engineering requires no second surgical site and is not restricted by a limited amount of material. Like bone grafting, tissue engineering reproduces natural bone tissue that can adapt to functional demands.

Original languageEnglish (US)
Title of host publicationBone Mechanics Handbook, Second Edition
PublisherCRC Press
ISBN (Electronic)9781420036589
ISBN (Print)9780849391170
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Hollister, S. J., Gabriel Chu, T. M., Halloran, J. W., & Feinberg, S. E. (2001). Design and manufacture of bone replacement scaffolds. In Bone Mechanics Handbook, Second Edition (pp. 36-1-36-14). CRC Press.