Design and Rationale of the Cognitive Intervention to Improve Memory in Heart Failure Patients Study

Susan J. Pressler, Bruno Giordani, Marita Titler, Irmina Gradus-Pizlo, Dean Smith, Susan G. Dorsey, Sujuan Gao, Miyeon Jung

Research output: Contribution to journalArticle


Background: Memory loss is an independent predictor of mortality among heart failure patients. Twenty-three percent to 50% of heart failure patients have comorbid memory loss, but few interventions are available to treat the memory loss. The aims of this 3-arm randomized controlled trial were to (1) evaluate efficacy of computerized cognitive training intervention using BrainHQ to improve primary outcomes of memory and serum brain-derived neurotrophic factor levels and secondary outcomes of working memory, instrumental activities of daily living, and health-related quality of life among heart failure patients; (2) evaluate incremental cost-effectiveness of BrainHQ; and (3) examine depressive symptoms and genomic moderators of BrainHQ effect. Methods: A sample of 264 heart failure patients within 4 equal-sized blocks (normal/low baseline cognitive function and gender) will be randomly assigned to (1) BrainHQ, (2) active control computer-based crossword puzzles, and (3) usual care control groups. BrainHQ is an 8-week, 40-hour program individualized to each patient's performance. Data collection will be completed at baseline and at 10 weeks and 4 and 8 months. Descriptive statistics, mixed model analyses, and cost-utility analysis using intent-to-treat approach will be computed. Conclusions: This research will provide new knowledge about the efficacy of BrainHQ to improve memory and increase serum brain-derived neurotrophic factor levels in heart failure. If efficacious, the intervention will provide a new therapeutic approach that is easy to disseminate to treat a serious comorbid condition of heart failure.

Original languageEnglish (US)
Pages (from-to)344-355
Number of pages12
JournalJournal of Cardiovascular Nursing
Issue number4
StatePublished - Jul 1 2018


  • apolipoprotein (APOE)-ϵ4
  • brain-derived neurotrophic factor
  • cognitive dysfunction
  • computerized cognitive training

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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