Abstract
A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.
Original language | English (US) |
---|---|
Pages (from-to) | 5121-5124 |
Number of pages | 4 |
Journal | Journal of Medicinal Chemistry |
Volume | 46 |
Issue number | 24 |
DOIs | |
State | Published - Nov 20 2003 |
Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
Cite this
Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. / Xu, Yanping; Mayhugh, Daniel; Saeed, Ashraf; Wang, Xiaodong; Thompson, Richard C.; Dominianni, Samuel J.; Kauffman, Raymond F.; Singh, Jaipal; Bean, James S.; Bensch, William R.; Barr, Robert J.; Osborne, John; Montrose-Rafizadeh, Chahrzad; Zink, Richard W.; Yumibe, Nathan P.; Huang, Naijia; Luffer-Atlas, Debra; Rungta, Deepa; Maise, Dale E.; Mantlo, Nathan B.
In: Journal of Medicinal Chemistry, Vol. 46, No. 24, 20.11.2003, p. 5121-5124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist
AU - Xu, Yanping
AU - Mayhugh, Daniel
AU - Saeed, Ashraf
AU - Wang, Xiaodong
AU - Thompson, Richard C.
AU - Dominianni, Samuel J.
AU - Kauffman, Raymond F.
AU - Singh, Jaipal
AU - Bean, James S.
AU - Bensch, William R.
AU - Barr, Robert J.
AU - Osborne, John
AU - Montrose-Rafizadeh, Chahrzad
AU - Zink, Richard W.
AU - Yumibe, Nathan P.
AU - Huang, Naijia
AU - Luffer-Atlas, Debra
AU - Rungta, Deepa
AU - Maise, Dale E.
AU - Mantlo, Nathan B.
PY - 2003/11/20
Y1 - 2003/11/20
N2 - A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.
AB - A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.
UR - http://www.scopus.com/inward/record.url?scp=0242522918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242522918&partnerID=8YFLogxK
U2 - 10.1021/jm034173l
DO - 10.1021/jm034173l
M3 - Article
C2 - 14613314
AN - SCOPUS:0242522918
VL - 46
SP - 5121
EP - 5124
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 24
ER -