Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Yanping Xu, Daniel Mayhugh, Ashraf Saeed, Xiaodong Wang, Richard C. Thompson, Samuel J. Dominianni, Raymond F. Kauffman, Jaipal Singh, James S. Bean, William R. Bensch, Robert J. Barr, John Osborne, Chahrzad Montrose-Rafizadeh, Richard W. Zink, Nathan P. Yumibe, Naijia Huang, Debra Luffer-Atlas, Deepa Rungta, Dale E. Maise, Nathan B. Mantlo

Research output: Contribution to journal › Article

64 Citations (Scopus)

Abstract

A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.

Original languageEnglish (US)
Pages (from-to)5121-5124
Number of pages4
JournalJournal of Medicinal Chemistry
Volume46
Issue number24
DOIs
StatePublished - Nov 20 2003
Externally publishedYes

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Peroxisome Proliferator-Activated Receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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Xu, Y., Mayhugh, D., Saeed, A., Wang, X., Thompson, R. C., Dominianni, S. J., ... Mantlo, N. B. (2003). Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. Journal of Medicinal Chemistry, 46(24), 5121-5124. https://doi.org/10.1021/jm034173l

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. / Xu, Yanping; Mayhugh, Daniel; Saeed, Ashraf; Wang, Xiaodong; Thompson, Richard C.; Dominianni, Samuel J.; Kauffman, Raymond F.; Singh, Jaipal; Bean, James S.; Bensch, William R.; Barr, Robert J.; Osborne, John; Montrose-Rafizadeh, Chahrzad; Zink, Richard W.; Yumibe, Nathan P.; Huang, Naijia; Luffer-Atlas, Debra; Rungta, Deepa; Maise, Dale E.; Mantlo, Nathan B.

In: Journal of Medicinal Chemistry, Vol. 46, No. 24, 20.11.2003, p. 5121-5124.

Research output: Contribution to journal › Article

Xu, Y, Mayhugh, D, Saeed, A, Wang, X, Thompson, RC, Dominianni, SJ, Kauffman, RF, Singh, J, Bean, JS, Bensch, WR, Barr, RJ, Osborne, J, Montrose-Rafizadeh, C, Zink, RW, Yumibe, NP, Huang, N, Luffer-Atlas, D, Rungta, D, Maise, DE & Mantlo, NB 2003, 'Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist', Journal of Medicinal Chemistry, vol. 46, no. 24, pp. 5121-5124. https://doi.org/10.1021/jm034173l
Xu Y, Mayhugh D, Saeed A, Wang X, Thompson RC, Dominianni SJ et al. Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. Journal of Medicinal Chemistry. 2003 Nov 20;46(24):5121-5124. https://doi.org/10.1021/jm034173l
Xu, Yanping ; Mayhugh, Daniel ; Saeed, Ashraf ; Wang, Xiaodong ; Thompson, Richard C. ; Dominianni, Samuel J. ; Kauffman, Raymond F. ; Singh, Jaipal ; Bean, James S. ; Bensch, William R. ; Barr, Robert J. ; Osborne, John ; Montrose-Rafizadeh, Chahrzad ; Zink, Richard W. ; Yumibe, Nathan P. ; Huang, Naijia ; Luffer-Atlas, Debra ; Rungta, Deepa ; Maise, Dale E. ; Mantlo, Nathan B. / Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. In: Journal of Medicinal Chemistry. 2003 ; Vol. 46, No. 24. pp. 5121-5124.
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AU - Thompson, Richard C.

AU - Dominianni, Samuel J.

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AU - Barr, Robert J.

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AU - Luffer-Atlas, Debra

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