Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Yanping Xu, Daniel Mayhugh, Ashraf Saeed, Xiaodong Wang, Richard C. Thompson, Samuel J. Dominianni, Raymond F. Kauffman, Jaipal Singh, James S. Bean, William R. Bensch, Robert J. Barr, John Osborne, Chahrzad Montrose-Rafizadeh, Richard W. Zink, Nathan P. Yumibe, Naijia Huang, Debra Luffer-Atlas, Deepa Rungta, Dale E. Maise, Nathan B. Mantlo

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARα agonist.

Original languageEnglish (US)
Pages (from-to)5121-5124
Number of pages4
JournalJournal of Medicinal Chemistry
Volume46
Issue number24
DOIs
StatePublished - Nov 20 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Xu, Y., Mayhugh, D., Saeed, A., Wang, X., Thompson, R. C., Dominianni, S. J., Kauffman, R. F., Singh, J., Bean, J. S., Bensch, W. R., Barr, R. J., Osborne, J., Montrose-Rafizadeh, C., Zink, R. W., Yumibe, N. P., Huang, N., Luffer-Atlas, D., Rungta, D., Maise, D. E., & Mantlo, N. B. (2003). Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist. Journal of Medicinal Chemistry, 46(24), 5121-5124. https://doi.org/10.1021/jm034173l