Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Seung Yub Lee, Fubo Liang, Xiao Ling Guo, Laiping Xie, Sean M. Cahill, Michael Blumenstein, Heyi Yang, David S. Lawrence, Zhong-Yin Zhang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

(Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.

Original languageEnglish (US)
Pages (from-to)4242-4244
Number of pages3
JournalAngewandte Chemie - International Edition
Volume44
Issue number27
DOIs
StatePublished - Jul 4 2005
Externally publishedYes

Fingerprint

Signal transduction
Chemical activation
Cell-Penetrating Peptides
Proteins
Diphtheria Toxin
Ricin
Disulfides
Peptides
Carrier Proteins

Keywords

  • Drug delivery
  • Inhibitors
  • Peptides
  • Prodrugs
  • Signal transduction

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor. / Lee, Seung Yub; Liang, Fubo; Guo, Xiao Ling; Xie, Laiping; Cahill, Sean M.; Blumenstein, Michael; Yang, Heyi; Lawrence, David S.; Zhang, Zhong-Yin.

In: Angewandte Chemie - International Edition, Vol. 44, No. 27, 04.07.2005, p. 4242-4244.

Research output: Contribution to journalArticle

Lee, Seung Yub ; Liang, Fubo ; Guo, Xiao Ling ; Xie, Laiping ; Cahill, Sean M. ; Blumenstein, Michael ; Yang, Heyi ; Lawrence, David S. ; Zhang, Zhong-Yin. / Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 27. pp. 4242-4244.
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